IMPDH2

GENE INFORMATION

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Gene name

IMPDH2

Synonyms

Description

IMP (inosine 5'-monophosphate) dehydrogenase 2 (HGNC Symbol)

Entrez gene summary

This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

p21.31

Chromosome location (bp)

49024325 - 49029408

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000178035 (version 78.38)

Entrez gene

3615

UniProt

P12268 (UniProt - Evidence at protein level)

neXtProt

NX_P12268

Antibodypedia

IMPDH2 antibodies
 

PROTEIN VIEW

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IMPDH2-001
 
IMPDH2-006
 
IMPDH2-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IMPDH2-001 ENSP00000321584
ENST00000326739
P12268
Show all »
Show » Show » 514 55.8 No 0
IMPDH2-006 ENSP00000393525
ENST00000429182
Q6RUP9
Show all »
Show » Show » 470 51 No 0
IMPDH2-010 ENSP00000403502
ENST00000442157
E7ETK5
Show all »
Show » Show » 279 30.6 No 0