GLDC

GENE INFORMATION

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Gene name

GLDC (HGNC Symbol)

Synonyms

GCSP, NKH

Description

Glycine dehydrogenase (decarboxylating) (HGNC Symbol)

Entrez gene summary

Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010]

Chromosome

9

Cytoband

p24.1

Chromosome location (bp)

6532464 - 6645650

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000178445 (version 78.38)

Entrez gene

2731

UniProt

P23378 (UniProt - Evidence at protein level)

neXtProt

NX_P23378

Antibodypedia

GLDC antibodies
 

PROTEIN VIEW

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GLDC-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GLDC-001 ENSP00000370737
ENST00000321612
P23378
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