CDH4

GENE INFORMATION

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Gene name

CDH4

Synonyms

Description

Cadherin 4, type 1, R-cadherin (retinal) (HGNC Symbol)

Entrez gene summary

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Chromosome

20

Cytoband

q13.33

Chromosome location (bp)

61252426 - 61940617

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000179242 (version 78.38)

Entrez gene

1002

UniProt

P55283 (UniProt - Evidence at transcript level)

neXtProt

NX_P55283

Antibodypedia

CDH4 antibodies
 

PROTEIN VIEW

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CDH4-001
 
CDH4-002
 
CDH4-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDH4-001 ENSP00000484928
ENST00000614565
P55283
Show all »
Show » Show » 916 100.3 Yes 1
CDH4-002 ENSP00000480844
ENST00000611855
Q8ND09
Show all »
Show » Show » 822 90.1 No 1
CDH4-003 ENSP00000443301
ENST00000543233
P55283
Show all »
Show » Show » 842 92.4 No 1