HLA-DQB1 - Gene info - The Human Protein Atlas

Gene name

HLA-DQB1 (HGNC Symbol)

Synonyms

CELIAC1, HLA-DQB, IDDM1

Description

Major histocompatibility complex, class II, DQ beta 1 (HGNC Symbol)

Entrez gene summary

HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Chromosome

Cytoband

p21.32

Chromosome location (bp)

32659467 - 32668383

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000179344 (version 78.38)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HLA-DQB1-001

ENSP00000407332
ENST00000434651

Q5Y7D6
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Q5Y7D6 [Target identity:100%; Query identity:100%]
HLA class II histocompatibility antigen, DQ beta 1 chain {ECO:0000313|Ensembl:ENSP00000382034}; MHC class II antigen {ECO:0000313|EMBL:AAU88009.1}; cDNA, FLJ79232, highly similar to HLA class II histocompatibility antigen, DQB1*0602 beta chain {ECO:0000313|EMBL:BAH14704.1}
Q67AJ0 [Target identity:89%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AAQ88044.1}
Q67AI9 [Target identity:89%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AAQ88045.1}
F8LFZ3 [Target identity:70%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:CCB96521.1}
U6EG31 [Target identity:70%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:CDI27934.1}
S6CPW3 [Target identity:70%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:CCH57522.1}
S6CPW2 [Target identity:70%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:CCH57517.1}
F8LFZ1 [Target identity:70%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:CCB96519.1}
I4EPK4 [Target identity:70%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:CCH35874.1}
I4EPK9 [Target identity:70%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:CCH35879.1}
O19741 [Target identity:36%; Query identity:100%]
HLA-DRB3 protein {ECO:0000313|EMBL:AAA59821.1}
L0BX86 [Target identity:34%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AFZ94679.1}
T1R348 [Target identity:34%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AGG79760.1}
R4QU49 [Target identity:34%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AGL73154.1}
L0BW29 [Target identity:34%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AFZ94661.1}
M4YQH8 [Target identity:34%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AGI48717.1}
L0BX94 [Target identity:34%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AFZ94689.1}
N0A4C3 [Target identity:34%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AGK44337.1}
N0A0M1 [Target identity:34%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AGK44334.1}
O78224 [Target identity:21%; Query identity:100%]
Lymphocyte antigen {ECO:0000313|EMBL:AAA59709.1}
Q5BLN3 [Target identity:13%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AAX22135.1}
Q5BLN2 [Target identity:13%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AAX22136.1}
Q4VC55 [Target identity:13%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AAY33733.1}
Q8MHQ2 [Target identity:12%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AAM28883.1}
Q8SNB9 [Target identity:12%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AAK96012.1}
Q9BCT8 [Target identity:12%; Query identity:100%]
MHC class II HLA-DQ-beta {ECO:0000313|EMBL:AAK17123.1}

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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0002504 [antigen processing and presentation of peptide or polysaccharide antigen via MHC class II]
GO:0005515 [protein binding]
GO:0006955 [immune response]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019882 [antigen processing and presentation]
GO:0042613 [MHC class II protein complex]

261

29.8

Yes

HLA-DQB1-002

ENSP00000364080
ENST00000374943

Q5SU54
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Q5SU54 [Target identity:100%; Query identity:100%]
HLA class II histocompatibility antigen, DQ beta 1 chain {ECO:0000313|Ensembl:ENSP00000364080}
Q67AJ0 [Target identity:86%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AAQ88044.1}
Q67AI9 [Target identity:86%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AAQ88045.1}
F8LFZ3 [Target identity:68%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:CCB96521.1}
U6EG31 [Target identity:68%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:CDI27934.1}
S6CPW3 [Target identity:68%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:CCH57522.1}
S6CPW2 [Target identity:68%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:CCH57517.1}
F8LFZ1 [Target identity:68%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:CCB96519.1}
I4EPK4 [Target identity:68%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:CCH35874.1}
I4EPK9 [Target identity:68%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:CCH35879.1}
O19741 [Target identity:34%; Query identity:100%]
HLA-DRB3 protein {ECO:0000313|EMBL:AAA59821.1}
L0BX86 [Target identity:33%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AFZ94679.1}
T1R348 [Target identity:33%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AGG79760.1}
R4QU49 [Target identity:33%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AGL73154.1}
L0BW29 [Target identity:33%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AFZ94661.1}
M4YQH8 [Target identity:33%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AGI48717.1}
L0BX94 [Target identity:33%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AFZ94689.1}
N0A4C3 [Target identity:33%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AGK44337.1}
N0A0M1 [Target identity:33%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AGK44334.1}
O78224 [Target identity:21%; Query identity:100%]
Lymphocyte antigen {ECO:0000313|EMBL:AAA59709.1}
Q5BLN3 [Target identity:13%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AAX22135.1}
Q5BLN2 [Target identity:13%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AAX22136.1}
Q4VC55 [Target identity:13%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AAY33733.1}
Q8MHQ2 [Target identity:11%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AAM28883.1}
Q8SNB9 [Target identity:11%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AAK96012.1}
Q9BCT8 [Target identity:11%; Query identity:100%]
MHC class II HLA-DQ-beta {ECO:0000313|EMBL:AAK17123.1}

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269

30.5

Yes

HLA-DQB1-003

ENSP00000382034
ENST00000399084

Q5Y7D6
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Show » « Hide

261

29.8

Yes

HLA-DQB1-004

ENSP00000382029
ENST00000399079

A2AAZ0
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A2AAZ0 [Target identity:100%; Query identity:100%]
HLA class II histocompatibility antigen, DQ beta 1 chain {ECO:0000313|Ensembl:ENSP00000382029}
F8LFZ1 [Target identity:81%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:CCB96519.1}
U6EG31 [Target identity:81%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:CDI27934.1}
S6CPW3 [Target identity:81%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:CCH57522.1}
S6CPW2 [Target identity:81%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:CCH57517.1}
F8LFZ3 [Target identity:81%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:CCB96521.1}
I4EPK4 [Target identity:81%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:CCH35874.1}
I4EPK9 [Target identity:81%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:CCH35879.1}
O19741 [Target identity:41%; Query identity:100%]
HLA-DRB3 protein {ECO:0000313|EMBL:AAA59821.1}
L0BX86 [Target identity:39%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AFZ94679.1}
T1R348 [Target identity:39%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AGG79760.1}
R4QU49 [Target identity:39%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AGL73154.1}
N0A4C3 [Target identity:39%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AGK44337.1}
N0A0M1 [Target identity:39%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AGK44334.1}
M4YQH8 [Target identity:39%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AGI48717.1}
L0BX94 [Target identity:39%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AFZ94689.1}
L0BW29 [Target identity:39%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AFZ94661.1}
O78224 [Target identity:25%; Query identity:100%]
Lymphocyte antigen {ECO:0000313|EMBL:AAA59709.1}
Q4VC55 [Target identity:16%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AAY33733.1}
Q5BLN2 [Target identity:16%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AAX22136.1}
Q5BLN3 [Target identity:16%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AAX22135.1}
Q8MHQ2 [Target identity:14%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AAM28883.1}
Q8SNB9 [Target identity:14%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AAK96012.1}
Q9BCT8 [Target identity:14%; Query identity:100%]
MHC class II HLA-DQ-beta {ECO:0000313|EMBL:AAK17123.1}

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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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224

Yes

HLA-DQB1-007

ENSP00000382032
ENST00000399082

A2AAY8
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A2AAY8 [Target identity:100%; Query identity:100%]
HLA class II histocompatibility antigen, DQ beta 1 chain {ECO:0000313|Ensembl:ENSP00000382032}
Q4VC55 [Target identity:26%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AAY33733.1}
Q5BLN2 [Target identity:26%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AAX22136.1}
Q5BLN3 [Target identity:26%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AAX22135.1}
Q8MHQ2 [Target identity:23%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AAM28883.1}
Q8SNB9 [Target identity:23%; Query identity:100%]
MHC class II antigen {ECO:0000313|EMBL:AAK96012.1}
Q9BCT8 [Target identity:23%; Query identity:100%]
MHC class II HLA-DQ-beta {ECO:0000313|EMBL:AAK17123.1}

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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0005515 [protein binding]
GO:0042612 [MHC class I protein complex]

134

15.2

Yes

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.