AKAP5

GENE INFORMATION

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Gene name

AKAP5 (HGNC Symbol)

Synonyms

AKAP75, AKAP79

Description

A kinase (PRKA) anchor protein 5 (HGNC Symbol)

Entrez gene summary

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q23.3

Chromosome location (bp)

64465499 - 64474503

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000179841 (version 78.38)

Entrez gene

9495

UniProt

P24588 (UniProt - Evidence at protein level)

neXtProt

NX_P24588

Antibodypedia

AKAP5 antibodies
 

PROTEIN VIEW

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AKAP5-001
 
AKAP5-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AKAP5-001 ENSP00000315615
ENST00000320636
P24588
Show all »
Show » Show » 427 47.1 No 0
AKAP5-002 ENSP00000378207
ENST00000394718
P24588
Show all »
Show » Show » 427 47.1 No 0