NQO1

GENE INFORMATION

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Gene name

NQO1 (HGNC Symbol)

Synonyms

DHQU, DIA4, DTD, NMOR1, QR1

Description

NAD(P)H dehydrogenase, quinone 1 (HGNC Symbol)

Entrez gene summary

This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

q22.1

Chromosome location (bp)

69706996 - 69726951

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000181019 (version 78.38)

Entrez gene

1728

UniProt

P15559 (UniProt - Evidence at protein level)

neXtProt

NX_P15559

Antibodypedia

NQO1 antibodies
 

PROTEIN VIEW

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NQO1-001
 
NQO1-002
 
NQO1-003
 
NQO1-004
 
NQO1-005
 
NQO1-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NQO1-001 ENSP00000319788
ENST00000320623
P15559
Show all »
Show » Show » 274 30.9 No 0
NQO1-002 ENSP00000368335
ENST00000379047
P15559
Show all »
Show » Show » 240 27.3 No 0
NQO1-003 ENSP00000456282
ENST00000561500
H3BRK3
Show all »
Show » 269 29.9 No 0
NQO1-004 ENSP00000368334
ENST00000379046
P15559
Show all »
Show » Show » 236 26.4 No 0
NQO1-005 ENSP00000455020
ENST00000564043
H3BNV2
Show all »
Show » Show » 253 28.5 No 0
NQO1-007 ENSP00000398330
ENST00000439109
B4DLR8
Show all »
Show » 202 22.8 No 0