RAD51B

GENE INFORMATION

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Gene name

RAD51B (HGNC Symbol)

Synonyms

hREC2, R51H2, RAD51L1, REC2

Description

RAD51 paralog B (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Jul 2011]

Chromosome

14

Cytoband

q24.1

Chromosome location (bp)

67819779 - 68730218

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000182185 (version 78.38)

Entrez gene

5890

UniProt

O15315 (UniProt - Evidence at protein level)

neXtProt

NX_O15315

Antibodypedia

RAD51B antibodies
 

PROTEIN VIEW

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RAD51B-001
 
RAD51B-003
 
RAD51B-004
 
RAD51B-005
 
RAD51B-006
 
RAD51B-014
 
RAD51B-021
 
RAD51B-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RAD51B-001 ENSP00000419881
ENST00000487861
C9JYJ0
Show all »
Show » Show » 425 46.5 No 0
RAD51B-003 ENSP00000418859
ENST00000471583
O15315
Show all »
Show » Show » 350 38.3 No 0
RAD51B-004 ENSP00000419471
ENST00000487270
O15315
Show all »
Show » Show » 384 42.2 No 0
RAD51B-005 ENSP00000420061
ENST00000488612
O15315
Show all »
Show » Show » 366 40.3 No 0
RAD51B-006 ENSP00000417948
ENST00000485181
C9J5S9
Show all »
Show » Show » 133 14.2 No 0
RAD51B-014 ENSP00000452044
ENST00000553334
G3V4W9
Show all »
Show » Show » 75 8.4 No 0
RAD51B-021 ENSP00000451616
ENST00000554575
H0YJI5
Show all »
Show » 35 3.9 No 0
RAD51B-201 ENSP00000375101
ENST00000390683
C9J5S9
Show all »
Show » Show » 279 31 No 1