GRIN2A - Gene info - The Human Protein Atlas

Gene name

GRIN2A (HGNC Symbol)

Synonyms

GluN2A, NMDAR2A

Description

Glutamate receptor, ionotropic, N-methyl D-aspartate 2A (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Chromosome

Cytoband

p13.2

Chromosome location (bp)

9753409 - 10182754

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000183454 (version 78.38)

Entrez gene

2903

UniProt

Q12879 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GRIN2A-001

ENSP00000379818
ENST00000396573

Q12879
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Q12879 [Direct mapping]
Glutamate receptor ionotropic, NMDA 2A
Q547U9 [Target identity:100%; Query identity:100%]
Glutamate receptor, ionotropic, N-methyl D-aspartate 2A {ECO:0000313|EMBL:EAW85187.1}; NMDA receptor subtype 2A gene {ECO:0000313|EMBL:AAN75825.1}

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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)

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GO:0001964 [startle response]
GO:0001975 [response to amphetamine]
GO:0004970 [ionotropic glutamate receptor activity]
GO:0004972 [N-methyl-D-aspartate selective glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005261 [cation channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006816 [calcium ion transport]
GO:0007215 [glutamate receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007611 [learning or memory]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0008021 [synaptic vesicle]
GO:0008104 [protein localization]
GO:0008270 [zinc ion binding]
GO:0008542 [visual learning]
GO:0009611 [response to wounding]
GO:0009986 [cell surface]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0017146 [N-methyl-D-aspartate selective glutamate receptor complex]
GO:0019233 [sensory perception of pain]
GO:0022008 [neurogenesis]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0030431 [sleep]
GO:0033058 [directional locomotion]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0040011 [locomotion]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042391 [regulation of membrane potential]
GO:0042417 [dopamine metabolic process]
GO:0042428 [serotonin metabolic process]
GO:0042493 [response to drug]
GO:0042734 [presynaptic membrane]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045471 [response to ethanol]
GO:0048167 [regulation of synaptic plasticity]
GO:0050804 [regulation of synaptic transmission]
GO:0051930 [regulation of sensory perception of pain]
GO:0060078 [regulation of postsynaptic membrane potential]
GO:0060079 [regulation of excitatory postsynaptic membrane potential]
GO:0070588 [calcium ion transmembrane transport]
GO:0097481 [neuronal postsynaptic density]
GO:0098655 [cation transmembrane transport]

1464

165.3

Yes

GRIN2A-002

ENSP00000332549
ENST00000330684

Q12879
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GO:0004970 [ionotropic glutamate receptor activity]
GO:0004972 [N-methyl-D-aspartate selective glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0007215 [glutamate receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007611 [learning or memory]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0017146 [N-methyl-D-aspartate selective glutamate receptor complex]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0045211 [postsynaptic membrane]
GO:0045471 [response to ethanol]

1464

165.3

Yes

GRIN2A-006

ENSP00000454998
ENST00000562109

Q12879
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Q12879 [Direct mapping]
Glutamate receptor ionotropic, NMDA 2A
F5GZ52 [Target identity:87%; Query identity:100%]
Glutamate receptor ionotropic, NMDA 2A {ECO:0000313|Ensembl:ENSP00000441572}

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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)

Show » « Hide

GO:0004970 [ionotropic glutamate receptor activity]
GO:0004972 [N-methyl-D-aspartate selective glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0007215 [glutamate receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007611 [learning or memory]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017146 [N-methyl-D-aspartate selective glutamate receptor complex]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0045211 [postsynaptic membrane]
GO:0045471 [response to ethanol]

1281

144.4

Yes

GRIN2A-201

ENSP00000379820
ENST00000396575

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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
RAS pathway related proteins
Protein evidence (Kim et al 2014)

Show » « Hide

GO:0004970 [ionotropic glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0016020 [membrane]

1327

150.7

GRIN2A-202

ENSP00000441572
ENST00000535259

F5GZ52
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F5GZ52 [Target identity:98%; Query identity:100%]
Glutamate receptor ionotropic, NMDA 2A {ECO:0000313|Ensembl:ENSP00000441572}

Show » « Hide

Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
RAS pathway related proteins
Protein evidence (Kim et al 2014)

Show » « Hide

GO:0004970 [ionotropic glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0045211 [postsynaptic membrane]

1144

129.8

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.