FBXL7

GENE INFORMATION

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Gene name

FBXL7 (HGNC Symbol)

Synonyms

FBL6, FBL7, KIAA0840

Description

F-box and leucine-rich repeat protein 7 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Chromosome

5

Cytoband

p15.1

Chromosome location (bp)

15500196 - 15939795

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000183580 (version 78.38)

Entrez gene

23194

UniProt

Q9UJT9 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9UJT9

Antibodypedia

FBXL7 antibodies
 

PROTEIN VIEW

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FBXL7-001
 
FBXL7-002
 
FBXL7-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FBXL7-001 ENSP00000423630
ENST00000504595
Q9UJT9
Show all »
Show » Show » 491 54.6 No 0
FBXL7-002 ENSP00000425184
ENST00000510662
Q9UJT9
Show all »
Show » Show » 444 49.8 No 0
FBXL7-201 ENSP00000329632
ENST00000329673
Show » Show » 449 50.4 No 0