LRTOMT

GENE INFORMATION

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Gene name

LRTOMT (HGNC Symbol)

Synonyms

CFAP111, COMT2, DFNB63, LRRC51

Description

Leucine rich transmembrane and O-methyltransferase domain containing (HGNC Symbol)

Entrez gene summary

This gene includes two transcript forms. The short form has one open reading frame (ORF), which encodes the leucine-rich repeats (LRR)-containing protein of unknown function. This protein is called LRTOMT1 or LRRC51. The long form has two alternative ORFs; the upstream ORF has the same translation start codon as used in the short form and the resulting transcript is a candidate for nonsense-mediated decay, and the downstream ORF encodes a different protein, which is a transmembrane catechol-O-methyltransferase and is called LRTOMT2, TOMT or COMT2. The COMT2 is essential for auditory and vestibular function. Defects in the COMT2 can cause nonsyndromic deafness. Alternatively spliced transcript variants from each transcript form have been found for this gene. [provided by RefSeq, Sep 2012]

Chromosome

11

Cytoband

q13.4

Chromosome location (bp)

72080331 - 72110782

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000184154 (version 78.38)

Entrez gene

220074

UniProt

Q8WZ04 (UniProt - Evidence at protein level), Q96E66 (UniProt - Evidence at transcript level)

neXtProt

NX_Q8WZ04, NX_Q96E66

Antibodypedia

LRTOMT antibodies
 

PROTEIN VIEW

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 « 
 
LRTOMT-001
 
LRTOMT-002
 
LRTOMT-003
 
LRTOMT-004
 
LRTOMT-006
 
LRTOMT-010
 
LRTOMT-011
 
LRTOMT-012
 
LRTOMT-014
 
LRTOMT-015
 
LRTOMT-016
 
LRTOMT-018
 
LRTOMT-020
 
LRTOMT-201
 
LRTOMT-202
 
LRTOMT-203
 
LRTOMT-204
 
LRTOMT-205
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LRTOMT-001 ENSP00000289488
ENST00000289488
Q96E66
Show all »
Show » Show » 192 22.2 No 0
LRTOMT-002 ENSP00000395139
ENST00000439209
C9JDG7
Show all »
Show » 156 18 No 0
LRTOMT-003 ENSP00000441249
ENST00000423494
Q96E66
Show all »
Show » Show » 174 20 No 0
LRTOMT-004 ENSP00000437649
ENST00000539587
F5H6F7
Show all »
Show » 43 4.5 No 0
LRTOMT-006 ENSP00000440693
ENST00000324866
Q96E66
Show all »
Show » Show » 146 16.8 No 0
LRTOMT-010 ENSP00000438522
ENST00000541614
Q96E66
Show all »
Show » Show » 158 18.1 No 0
LRTOMT-011 ENSP00000438762
ENST00000538413
F5H0M6
Show all »
Show » 92 10.7 No 0
LRTOMT-012 ENSP00000442267
ENST00000539271
F5H6F7
Show all »
Show » 43 4.5 No 0
LRTOMT-014 ENSP00000444583
ENST00000538478
Q96E66
Show all »
Show » Show » 192 22.2 No 0
LRTOMT-015 ENSP00000440248
ENST00000542846
F5GYI0
Show all »
Show » 104 12.1 No 0
LRTOMT-016 ENSP00000443421
ENST00000536917
Q96E66
Show all »
Show » Show » 146 16.8 No 0
LRTOMT-018 ENSP00000437985
ENST00000537483
F5H614
Show all »
Show » 65 7.5 No 0
LRTOMT-020 ENSP00000390485
ENST00000440313
F8WBA5
Show all »
Show » 47 5.1 No 0
LRTOMT-201 ENSP00000305742
ENST00000307198
Q8WZ04
Show all »
Show » Show » 291 32.2 No 1
LRTOMT-202 ENSP00000392233
ENST00000419228
Q8WZ04
Show all »
Show » Show » 155 17.4 No 0
LRTOMT-203 ENSP00000409789
ENST00000435085
Q8WZ04
Show all »
Show » Show » 291 32.2 No 1
LRTOMT-204 ENSP00000414271
ENST00000447974
Q96E66
Show all »
Show » Show » 192 22.2 No 0
LRTOMT-205 ENSP00000482923
ENST00000615940
Q96E66
Show all »
Show » Show » 174 20 No 0