PROS1

GENE INFORMATION

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Gene name

PROS1 (HGNC Symbol)

Synonyms

PROS

Description

Protein S (alpha) (HGNC Symbol)

Entrez gene summary

This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. [provided by RefSeq, Feb 2009]

Chromosome

3

Cytoband

q11.1

Chromosome location (bp)

93873033 - 93974066

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000184500 (version 78.38)

Entrez gene

5627

UniProt

P07225 (UniProt - Evidence at protein level)

neXtProt

NX_P07225

Antibodypedia

PROS1 antibodies
 

PROTEIN VIEW

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PROS1-001
 
PROS1-002
 
PROS1-003
 
PROS1-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PROS1-001 ENSP00000377783
ENST00000394236
P07225
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Show » Show » 676 75.1 Yes 0
PROS1-002 ENSP00000385794
ENST00000407433
G5E9F8
Show all »
Show » Show » 545 60.4 No 0
PROS1-003 ENSP00000330021
ENST00000348974
H7BXT0
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Show » Show » 231 25.9 Yes 1
PROS1-004 ENSP00000419616
ENST00000472684
C9K0R0
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Show » Show » 56 6.1 No 0