TMEM173

GENE INFORMATION

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Gene name

TMEM173 (HGNC Symbol)

Synonyms

FLJ38577, NET23

Description

Transmembrane protein 173 (HGNC Symbol)

Entrez gene summary

This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Chromosome

5

Cytoband

q31.2

Chromosome location (bp)

139475534 - 139482935

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000184584 (version 78.38)

Entrez gene

340061

UniProt

Q86WV6 (UniProt - Evidence at protein level)

neXtProt

NX_Q86WV6

Antibodypedia

TMEM173 antibodies
 

PROTEIN VIEW

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TMEM173-001
 
TMEM173-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TMEM173-001 ENSP00000331288
ENST00000330794
Q86WV6
Show all »
Show » Show » 379 42.2 No 3
TMEM173-006 ENSP00000427455
ENST00000510817
J3QTB1
Show all »
Show » Show » 253 28.2 No 3