CLCNKB

GENE INFORMATION

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Gene name

CLCNKB (HGNC Symbol)

Synonyms

hClC-Kb

Description

Chloride channel, voltage-sensitive Kb (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt reabsorption. Mutations in this gene are associated with autosomal recessive Bartter syndrome type 3 (BS3). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

1

Cytoband

p36.13

Chromosome location (bp)

16043736 - 16057308

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000184908 (version 78.38)

Entrez gene

1188

UniProt

P51801 (UniProt - Evidence at protein level)

neXtProt

NX_P51801

Antibodypedia

CLCNKB antibodies
 

PROTEIN VIEW

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CLCNKB-001
 
CLCNKB-002
 
CLCNKB-003
 
CLCNKB-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CLCNKB-001 ENSP00000364831
ENST00000375679
P51801
Show all »
Show » Show » 687 75.4 No >9
CLCNKB-002 ENSP00000364819
ENST00000375667
P51801
Show all »
Show » Show » 517 57 No 7
CLCNKB-003 ENSP00000389344
ENST00000431772
Q5T5Q6
Show all »
Show » Show » 146 16 No 0
CLCNKB-201 ENSP00000483866
ENST00000619181
Show » Show » 463 50.8 No >9