PDE6G

GENE INFORMATION

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Gene name

PDE6G (HGNC Symbol)

Synonyms

PDEG, RP57

Description

Phosphodiesterase 6G, cGMP-specific, rod, gamma (HGNC Symbol)

Entrez gene summary

This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

Chromosome

17

Cytoband

q25.3

Chromosome location (bp)

81650459 - 81663112

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000185527 (version 78.38)

Entrez gene

5148

UniProt

P18545 (UniProt - Evidence at protein level)

neXtProt

NX_P18545

Antibodypedia

PDE6G antibodies
 

PROTEIN VIEW

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PDE6G-001
 
PDE6G-002
 
PDE6G-003
 
PDE6G-005
 
PDE6G-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PDE6G-001 ENSP00000461464
ENST00000571004
P18545
Show all »
Show » Show » 87 9.6 No 0
PDE6G-002 ENSP00000458567
ENST00000573076
P18545
Show all »
Show » Show » 137 15.1 No 0
PDE6G-003 ENSP00000460962
ENST00000574024
I3L446
Show all »
Show » 70 7.5 No 0
PDE6G-005 ENSP00000458167
ENST00000571224
P18545
Show all »
Show » Show » 87 9.6 No 0
PDE6G-201 ENSP00000328412
ENST00000331056
P18545
Show all »
Show » Show » 87 9.6 No 0