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GENE INFORMATION
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The gene information section lists the gene name (HUGO Gene Nomenclature Committee ( HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version.
The Entrez gene identifier for the gene is also given. If any of the protein products of
the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the
neXtProt databases for these proteins are displayed.
There is also a link to the Antibodypedia portal where validation data for antibodies produced by other suppliers
against this gene can be found.
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Gene name |
ATP6V0C (HGNC Symbol) |
Synonyms |
ATP6C, ATP6L, ATPL, VATL, Vma3 |
Description |
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c (HGNC Symbol) |
Entrez gene summary |
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c"", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010] |
Chromosome |
16 |
Cytoband |
p13.3 |
Chromosome location (bp) |
2513726 - 2520223 |
Protein evidence |
Evidence at protein level (all genes) |
Ensembl |
ENSG00000185883 (version 78.38) |
Entrez gene |
527 |
UniProt |
P27449 (UniProt - Evidence at protein level) |
neXtProt |
NX_P27449 |
Antibodypedia |
ATP6V0C antibodies |
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PROTEIN VIEW
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The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues
(HsID 10) or 50 aa residues (HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS,
SignalP 4.0, and
Phobius
(turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green.
Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed
( read more), and at the bottom of the protein view is the protein scale.
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PROTEIN INFORMATION
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The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant.
The data in the UniProt column can be expanded to show links to all matching
UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors
SPOCTOPUS,
SignalP 4.0, and
Phobius) and the number of predicted transmembrane region(s) (according to
MDM) are also reported.
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Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length (aa) |
Molecular mass (kDa) |
Signal peptide (predicted) |
Transmembrane regions (predicted)
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ATP6V0C-001 |
ENSP00000329757
ENST00000330398
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P27449 Show all »
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P27449 [Direct mapping]V-type proton ATPase 16 kDa proteolipid subunit H3BNI4 [Target identity:72%; Query identity:100%]ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c {ECO:0000313|EMBL:EAW85501.1}; V-type proton ATPase 16 kDa proteolipid subunit {ECO:0000313|Ensembl:ENSP00000454868} Q8NHD7 [Target identity:16%; Query identity:100%]V-ATPase subunit c {ECO:0000313|EMBL:BAC06442.1}
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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155 |
15.7 |
No |
3 |
ATP6V0C-003 |
ENSP00000454597
ENST00000568562
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H3BMY0 Show all »
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H3BMY0 [Target identity:100%; Query identity:100%]V-type proton ATPase 16 kDa proteolipid subunit {ECO:0000313|Ensembl:ENSP00000454597}
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Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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63 |
7.1 |
No |
0 |
ATP6V0C-004 |
ENSP00000457782
ENST00000565223
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H3BNI4 Show all »
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H3BNI4 [Target identity:100%; Query identity:100%]ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c {ECO:0000313|EMBL:EAW85501.1}; V-type proton ATPase 16 kDa proteolipid subunit {ECO:0000313|Ensembl:ENSP00000454868}
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0033177 [proton-transporting two-sector ATPase complex, proton-transporting domain] GO:0033179 [proton-transporting V-type ATPase, V0 domain]
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112 |
11.6 |
No |
3 |
ATP6V0C-005 |
ENSP00000454868
ENST00000564973
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H3BNI4 Show all »
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H3BNI4 [Target identity:100%; Query identity:100%]ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c {ECO:0000313|EMBL:EAW85501.1}; V-type proton ATPase 16 kDa proteolipid subunit {ECO:0000313|Ensembl:ENSP00000454868}
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Show »
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0033177 [proton-transporting two-sector ATPase complex, proton-transporting domain] GO:0033179 [proton-transporting V-type ATPase, V0 domain]
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112 |
11.6 |
No |
3 |
ATP6V0C-201 |
ENSP00000481778
ENST00000618152
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P27449 Show all »
« Hide
P27449 [Direct mapping]V-type proton ATPase 16 kDa proteolipid subunit H3BNI4 [Target identity:72%; Query identity:100%]ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c {ECO:0000313|EMBL:EAW85501.1}; V-type proton ATPase 16 kDa proteolipid subunit {ECO:0000313|Ensembl:ENSP00000454868} Q8NHD7 [Target identity:16%; Query identity:100%]V-ATPase subunit c {ECO:0000313|EMBL:BAC06442.1}
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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155 |
15.7 |
No |
3 |
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