PTCH1 - Gene info - The Human Protein Atlas

PTCH1

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

? »

Gene name	PTCH1 (HGNC Symbol)
Synonyms	BCNS, NBCCS, PTCH
Description	Patched 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q22.32
Chromosome location (bp)	95442980 - 95517057
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185920 (version 78.38)
Entrez gene	5727
UniProt	Q13635 (UniProt - Evidence at protein level)
neXtProt	NX_Q13635
Antibodypedia	PTCH1 antibodies

PROTEIN VIEW

? »

PTCH1-001		PTCH1-002		PTCH1-003		PTCH1-005		PTCH1-006		PTCH1-007		PTCH1-009		PTCH1-010		PTCH1-011		PTCH1-012		PTCH1-019		PTCH1-020		PTCH1-201		PTCH1-202		PTCH1-203

PROTEIN INFORMATION

? »

Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
PTCH1-001	ENSP00000332353 ENST00000331920	Q13635 Show all » « Hide Q13635 [Direct mapping] Protein patched homolog 1 Q6TKQ0 [Target identity:7%; Query identity:100%] Patched {ECO:0000313\|EMBL:AAR21238.1} F8VQS6 [Target identity:6%; Query identity:100%] Protein patched homolog 1 {ECO:0000313\|Ensembl:ENSP00000450131} F8VXL8 [Target identity:4%; Query identity:100%] Protein patched homolog 1 {ECO:0000313\|Ensembl:ENSP00000449078}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0001701 [in utero embryonic development] GO:0001841 [neural tube formation] GO:0001843 [neural tube closure] GO:0003007 [heart morphogenesis] GO:0005113 [patched binding] GO:0005119 [smoothened binding] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0007165 [signal transduction] GO:0007224 [smoothened signaling pathway] GO:0007346 [regulation of mitotic cell cycle] GO:0007389 [pattern specification process] GO:0007420 [brain development] GO:0008158 [hedgehog receptor activity] GO:0008201 [heparin binding] GO:0008285 [negative regulation of cell proliferation] GO:0008544 [epidermis development] GO:0008589 [regulation of smoothened signaling pathway] GO:0009612 [response to mechanical stimulus] GO:0009887 [organ morphogenesis] GO:0009953 [dorsal/ventral pattern formation] GO:0010157 [response to chlorate] GO:0010875 [positive regulation of cholesterol efflux] GO:0014069 [postsynaptic density] GO:0014070 [response to organic cyclic compound] GO:0015485 [cholesterol binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0021522 [spinal cord motor neuron differentiation] GO:0021532 [neural tube patterning] GO:0021904 [dorsal/ventral neural tube patterning] GO:0021997 [neural plate axis specification] GO:0030326 [embryonic limb morphogenesis] GO:0030332 [cyclin binding] GO:0030496 [midbody] GO:0030879 [mammary gland development] GO:0032355 [response to estradiol] GO:0032403 [protein complex binding] GO:0032526 [response to retinoic acid] GO:0032880 [regulation of protein localization] GO:0035108 [limb morphogenesis] GO:0035137 [hindlimb morphogenesis] GO:0040008 [regulation of growth] GO:0040015 [negative regulation of multicellular organism growth] GO:0042127 [regulation of cell proliferation] GO:0042493 [response to drug] GO:0042593 [glucose homeostasis] GO:0043231 [intracellular membrane-bounded organelle] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043616 [keratinocyte proliferation] GO:0044294 [dendritic growth cone] GO:0044295 [axonal growth cone] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045879 [negative regulation of smoothened signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0048568 [embryonic organ development] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0051782 [negative regulation of cell division] GO:0060037 [pharyngeal system development] GO:0060603 [mammary gland duct morphogenesis] GO:0060644 [mammary gland epithelial cell differentiation] GO:0060831 [smoothened signaling pathway involved in dorsal/ventral neural tube patterning] GO:0061005 [cell differentiation involved in kidney development] GO:0061053 [somite development] GO:0071397 [cellular response to cholesterol] GO:0072001 [renal system development] GO:0072203 [cell proliferation involved in metanephros development] GO:0072372 [primary cilium] GO:0072661 [protein targeting to plasma membrane] GO:0097108 [hedgehog family protein binding]	1447	160.5	No	>9
PTCH1-002	ENSP00000414823 ENST00000429896	Q13635 Show all » « Hide Q13635 [Direct mapping] Protein patched homolog 1 Q6TKQ0 [Target identity:8%; Query identity:100%] Patched {ECO:0000313\|EMBL:AAR21238.1} F8VQS6 [Target identity:7%; Query identity:100%] Protein patched homolog 1 {ECO:0000313\|Ensembl:ENSP00000450131} F8VXL8 [Target identity:5%; Query identity:100%] Protein patched homolog 1 {ECO:0000313\|Ensembl:ENSP00000449078}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005119 [smoothened binding] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0007224 [smoothened signaling pathway] GO:0007420 [brain development] GO:0008158 [hedgehog receptor activity] GO:0008589 [regulation of smoothened signaling pathway] GO:0009887 [organ morphogenesis] GO:0009953 [dorsal/ventral pattern formation] GO:0010875 [positive regulation of cholesterol efflux] GO:0015485 [cholesterol binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0021532 [neural tube patterning] GO:0021997 [neural plate axis specification] GO:0030326 [embryonic limb morphogenesis] GO:0030332 [cyclin binding] GO:0035108 [limb morphogenesis] GO:0040015 [negative regulation of multicellular organism growth] GO:0043231 [intracellular membrane-bounded organelle] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045879 [negative regulation of smoothened signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0060037 [pharyngeal system development] GO:0061053 [somite development] GO:0071397 [cellular response to cholesterol] GO:0072001 [renal system development] GO:0072661 [protein targeting to plasma membrane] GO:0097108 [hedgehog family protein binding]	1296	144.4	No	>9
PTCH1-003	ENSP00000410287 ENST00000430669	Q13635 Show all » « Hide Q13635 [Direct mapping] Protein patched homolog 1 Q6TKQ0 [Target identity:7%; Query identity:100%] Patched {ECO:0000313\|EMBL:AAR21238.1} F8VQS6 [Target identity:6%; Query identity:100%] Protein patched homolog 1 {ECO:0000313\|Ensembl:ENSP00000450131} F8VXL8 [Target identity:4%; Query identity:100%] Protein patched homolog 1 {ECO:0000313\|Ensembl:ENSP00000449078}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005119 [smoothened binding] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0007224 [smoothened signaling pathway] GO:0007420 [brain development] GO:0008158 [hedgehog receptor activity] GO:0008589 [regulation of smoothened signaling pathway] GO:0009887 [organ morphogenesis] GO:0009953 [dorsal/ventral pattern formation] GO:0010875 [positive regulation of cholesterol efflux] GO:0015485 [cholesterol binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0021532 [neural tube patterning] GO:0021997 [neural plate axis specification] GO:0030326 [embryonic limb morphogenesis] GO:0030332 [cyclin binding] GO:0035108 [limb morphogenesis] GO:0040015 [negative regulation of multicellular organism growth] GO:0043231 [intracellular membrane-bounded organelle] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045879 [negative regulation of smoothened signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0060037 [pharyngeal system development] GO:0061053 [somite development] GO:0071397 [cellular response to cholesterol] GO:0072001 [renal system development] GO:0072661 [protein targeting to plasma membrane] GO:0097108 [hedgehog family protein binding]	1381	153.9	No	>9
PTCH1-005	ENSP00000364420 ENST00000375271	H0Y3B8 Show all » « Hide H0Y3B8 [Target identity:100%; Query identity:100%] Protein patched homolog 1 {ECO:0000313\|Ensembl:ENSP00000364420} Q3LFT4 [Target identity:98%; Query identity:100%] PTCH protein-10 {ECO:0000313\|EMBL:BAE45302.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations	Show » « Hide GO:0008158 [hedgehog receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane]	352	39.3	No	3
PTCH1-006	ENSP00000449745 ENST00000468211	Q13635 Show all » « Hide Q13635 [Direct mapping] Protein patched homolog 1 F8VQS6 [Target identity:50%; Query identity:100%] Protein patched homolog 1 {ECO:0000313\|Ensembl:ENSP00000450131}	Show » « Hide MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005119 [smoothened binding] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0007224 [smoothened signaling pathway] GO:0007420 [brain development] GO:0008158 [hedgehog receptor activity] GO:0008589 [regulation of smoothened signaling pathway] GO:0009887 [organ morphogenesis] GO:0009953 [dorsal/ventral pattern formation] GO:0010875 [positive regulation of cholesterol efflux] GO:0015485 [cholesterol binding] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0021532 [neural tube patterning] GO:0021997 [neural plate axis specification] GO:0030326 [embryonic limb morphogenesis] GO:0030332 [cyclin binding] GO:0035108 [limb morphogenesis] GO:0040015 [negative regulation of multicellular organism growth] GO:0043231 [intracellular membrane-bounded organelle] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045879 [negative regulation of smoothened signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0060037 [pharyngeal system development] GO:0061053 [somite development] GO:0071397 [cellular response to cholesterol] GO:0072001 [renal system development] GO:0072661 [protein targeting to plasma membrane] GO:0097108 [hedgehog family protein binding]	183	20.8	No	0
PTCH1-007	ENSP00000364423 ENST00000375274	Q13635 Show all » « Hide Q13635 [Direct mapping] Protein patched homolog 1 Q6TKQ0 [Target identity:7%; Query identity:100%] Patched {ECO:0000313\|EMBL:AAR21238.1} F8VQS6 [Target identity:6%; Query identity:100%] Protein patched homolog 1 {ECO:0000313\|Ensembl:ENSP00000450131} F8VXL8 [Target identity:4%; Query identity:100%] Protein patched homolog 1 {ECO:0000313\|Ensembl:ENSP00000449078} A3KBF6 [Target identity:1%; Query identity:100%] Patched homolog 1 splice variant 1C variant {ECO:0000313\|EMBL:BAF47711.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005119 [smoothened binding] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0007224 [smoothened signaling pathway] GO:0007420 [brain development] GO:0008158 [hedgehog receptor activity] GO:0008589 [regulation of smoothened signaling pathway] GO:0009887 [organ morphogenesis] GO:0009953 [dorsal/ventral pattern formation] GO:0010875 [positive regulation of cholesterol efflux] GO:0015485 [cholesterol binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0021532 [neural tube patterning] GO:0021997 [neural plate axis specification] GO:0030326 [embryonic limb morphogenesis] GO:0030332 [cyclin binding] GO:0035108 [limb morphogenesis] GO:0040015 [negative regulation of multicellular organism growth] GO:0043231 [intracellular membrane-bounded organelle] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045879 [negative regulation of smoothened signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0060037 [pharyngeal system development] GO:0061053 [somite development] GO:0071397 [cellular response to cholesterol] GO:0072001 [renal system development] GO:0072661 [protein targeting to plasma membrane] GO:0097108 [hedgehog family protein binding]	1446	161	No	>9
PTCH1-009	ENSP00000447878 ENST00000547672	Q13635 Show all » « Hide Q13635 [Direct mapping] Protein patched homolog 1 F8VQS6 [Target identity:52%; Query identity:100%] Protein patched homolog 1 {ECO:0000313\|Ensembl:ENSP00000450131}	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005119 [smoothened binding] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0007224 [smoothened signaling pathway] GO:0007420 [brain development] GO:0008158 [hedgehog receptor activity] GO:0008589 [regulation of smoothened signaling pathway] GO:0009887 [organ morphogenesis] GO:0009953 [dorsal/ventral pattern formation] GO:0010875 [positive regulation of cholesterol efflux] GO:0015485 [cholesterol binding] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0021532 [neural tube patterning] GO:0021997 [neural plate axis specification] GO:0030326 [embryonic limb morphogenesis] GO:0030332 [cyclin binding] GO:0035108 [limb morphogenesis] GO:0040015 [negative regulation of multicellular organism growth] GO:0043231 [intracellular membrane-bounded organelle] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045879 [negative regulation of smoothened signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0060037 [pharyngeal system development] GO:0061053 [somite development] GO:0071397 [cellular response to cholesterol] GO:0072001 [renal system development] GO:0072661 [protein targeting to plasma membrane] GO:0097108 [hedgehog family protein binding]	174	19.9	No	0
PTCH1-010	ENSP00000448843 ENST00000546820	Q13635 Show all » « Hide Q13635 [Direct mapping] Protein patched homolog 1 F8VQS6 [Target identity:52%; Query identity:100%] Protein patched homolog 1 {ECO:0000313\|Ensembl:ENSP00000450131}	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005119 [smoothened binding] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0007224 [smoothened signaling pathway] GO:0007420 [brain development] GO:0008158 [hedgehog receptor activity] GO:0008589 [regulation of smoothened signaling pathway] GO:0009887 [organ morphogenesis] GO:0009953 [dorsal/ventral pattern formation] GO:0010875 [positive regulation of cholesterol efflux] GO:0015485 [cholesterol binding] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0021532 [neural tube patterning] GO:0021997 [neural plate axis specification] GO:0030326 [embryonic limb morphogenesis] GO:0030332 [cyclin binding] GO:0035108 [limb morphogenesis] GO:0040015 [negative regulation of multicellular organism growth] GO:0043231 [intracellular membrane-bounded organelle] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045879 [negative regulation of smoothened signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0060037 [pharyngeal system development] GO:0061053 [somite development] GO:0071397 [cellular response to cholesterol] GO:0072001 [renal system development] GO:0072661 [protein targeting to plasma membrane] GO:0097108 [hedgehog family protein binding]	174	19.9	No	0
PTCH1-011	ENSP00000447008 ENST00000551845	Q13635 Show all » « Hide Q13635 [Direct mapping] Protein patched homolog 1 F8VQS6 [Target identity:52%; Query identity:100%] Protein patched homolog 1 {ECO:0000313\|Ensembl:ENSP00000450131}	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005119 [smoothened binding] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0007224 [smoothened signaling pathway] GO:0007420 [brain development] GO:0008158 [hedgehog receptor activity] GO:0008589 [regulation of smoothened signaling pathway] GO:0009887 [organ morphogenesis] GO:0009953 [dorsal/ventral pattern formation] GO:0010875 [positive regulation of cholesterol efflux] GO:0015485 [cholesterol binding] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0021532 [neural tube patterning] GO:0021997 [neural plate axis specification] GO:0030326 [embryonic limb morphogenesis] GO:0030332 [cyclin binding] GO:0035108 [limb morphogenesis] GO:0040015 [negative regulation of multicellular organism growth] GO:0043231 [intracellular membrane-bounded organelle] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045879 [negative regulation of smoothened signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0060037 [pharyngeal system development] GO:0061053 [somite development] GO:0071397 [cellular response to cholesterol] GO:0072001 [renal system development] GO:0072661 [protein targeting to plasma membrane] GO:0097108 [hedgehog family protein binding]	174	19.9	No	0
PTCH1-012	ENSP00000447797 ENST00000553011	Q13635 Show all » « Hide Q13635 [Direct mapping] Protein patched homolog 1 F8VQS6 [Target identity:52%; Query identity:100%] Protein patched homolog 1 {ECO:0000313\|Ensembl:ENSP00000450131}	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005119 [smoothened binding] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0007224 [smoothened signaling pathway] GO:0007420 [brain development] GO:0008158 [hedgehog receptor activity] GO:0008589 [regulation of smoothened signaling pathway] GO:0009887 [organ morphogenesis] GO:0009953 [dorsal/ventral pattern formation] GO:0010875 [positive regulation of cholesterol efflux] GO:0015485 [cholesterol binding] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0021532 [neural tube patterning] GO:0021997 [neural plate axis specification] GO:0030326 [embryonic limb morphogenesis] GO:0030332 [cyclin binding] GO:0035108 [limb morphogenesis] GO:0040015 [negative regulation of multicellular organism growth] GO:0043231 [intracellular membrane-bounded organelle] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045879 [negative regulation of smoothened signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0060037 [pharyngeal system development] GO:0061053 [somite development] GO:0071397 [cellular response to cholesterol] GO:0072001 [renal system development] GO:0072661 [protein targeting to plasma membrane] GO:0097108 [hedgehog family protein binding]	174	19.9	No	0
PTCH1-019	ENSP00000449078 ENST00000548420	F8VXL8 Show all » « Hide F8VXL8 [Target identity:98%; Query identity:100%] Protein patched homolog 1 {ECO:0000313\|Ensembl:ENSP00000449078}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations		67	7.3	No	0
PTCH1-020	ENSP00000450131 ENST00000551630	F8VQS6 Show all » « Hide F8VQS6 [Target identity:100%; Query identity:100%] Protein patched homolog 1 {ECO:0000313\|Ensembl:ENSP00000450131}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations		92	10.7	No	0
PTCH1-201	ENSP00000396135 ENST00000418258	Q13635 Show all » « Hide Q13635 [Direct mapping] Protein patched homolog 1 Q6TKQ0 [Target identity:8%; Query identity:100%] Patched {ECO:0000313\|EMBL:AAR21238.1} F8VQS6 [Target identity:7%; Query identity:100%] Protein patched homolog 1 {ECO:0000313\|Ensembl:ENSP00000450131} F8VXL8 [Target identity:5%; Query identity:100%] Protein patched homolog 1 {ECO:0000313\|Ensembl:ENSP00000449078}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005119 [smoothened binding] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0007224 [smoothened signaling pathway] GO:0007420 [brain development] GO:0008158 [hedgehog receptor activity] GO:0008589 [regulation of smoothened signaling pathway] GO:0009887 [organ morphogenesis] GO:0009953 [dorsal/ventral pattern formation] GO:0010875 [positive regulation of cholesterol efflux] GO:0015485 [cholesterol binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0021532 [neural tube patterning] GO:0021997 [neural plate axis specification] GO:0030326 [embryonic limb morphogenesis] GO:0030332 [cyclin binding] GO:0035108 [limb morphogenesis] GO:0040015 [negative regulation of multicellular organism growth] GO:0043231 [intracellular membrane-bounded organelle] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045879 [negative regulation of smoothened signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0060037 [pharyngeal system development] GO:0061053 [somite development] GO:0071397 [cellular response to cholesterol] GO:0072001 [renal system development] GO:0072661 [protein targeting to plasma membrane] GO:0097108 [hedgehog family protein binding]	1296	144.4	No	>9
PTCH1-202	ENSP00000399981 ENST00000421141	Q13635 Show all » « Hide Q13635 [Direct mapping] Protein patched homolog 1 Q6TKQ0 [Target identity:8%; Query identity:100%] Patched {ECO:0000313\|EMBL:AAR21238.1} F8VQS6 [Target identity:7%; Query identity:100%] Protein patched homolog 1 {ECO:0000313\|Ensembl:ENSP00000450131} F8VXL8 [Target identity:5%; Query identity:100%] Protein patched homolog 1 {ECO:0000313\|Ensembl:ENSP00000449078}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005119 [smoothened binding] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0007224 [smoothened signaling pathway] GO:0007420 [brain development] GO:0008158 [hedgehog receptor activity] GO:0008589 [regulation of smoothened signaling pathway] GO:0009887 [organ morphogenesis] GO:0009953 [dorsal/ventral pattern formation] GO:0010875 [positive regulation of cholesterol efflux] GO:0015485 [cholesterol binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0021532 [neural tube patterning] GO:0021997 [neural plate axis specification] GO:0030326 [embryonic limb morphogenesis] GO:0030332 [cyclin binding] GO:0035108 [limb morphogenesis] GO:0040015 [negative regulation of multicellular organism growth] GO:0043231 [intracellular membrane-bounded organelle] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045879 [negative regulation of smoothened signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0060037 [pharyngeal system development] GO:0061053 [somite development] GO:0071397 [cellular response to cholesterol] GO:0072001 [renal system development] GO:0072661 [protein targeting to plasma membrane] GO:0097108 [hedgehog family protein binding]	1296	144.4	No	>9
PTCH1-203	ENSP00000389744 ENST00000437951	Q13635 Show all » « Hide Q13635 [Direct mapping] Protein patched homolog 1 Q6TKQ0 [Target identity:7%; Query identity:100%] Patched {ECO:0000313\|EMBL:AAR21238.1} F8VQS6 [Target identity:6%; Query identity:100%] Protein patched homolog 1 {ECO:0000313\|Ensembl:ENSP00000450131} F8VXL8 [Target identity:4%; Query identity:100%] Protein patched homolog 1 {ECO:0000313\|Ensembl:ENSP00000449078}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005119 [smoothened binding] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0007224 [smoothened signaling pathway] GO:0007420 [brain development] GO:0008158 [hedgehog receptor activity] GO:0008589 [regulation of smoothened signaling pathway] GO:0009887 [organ morphogenesis] GO:0009953 [dorsal/ventral pattern formation] GO:0010875 [positive regulation of cholesterol efflux] GO:0015485 [cholesterol binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0021532 [neural tube patterning] GO:0021997 [neural plate axis specification] GO:0030326 [embryonic limb morphogenesis] GO:0030332 [cyclin binding] GO:0035108 [limb morphogenesis] GO:0040015 [negative regulation of multicellular organism growth] GO:0043231 [intracellular membrane-bounded organelle] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045879 [negative regulation of smoothened signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0060037 [pharyngeal system development] GO:0061053 [somite development] GO:0071397 [cellular response to cholesterol] GO:0072001 [renal system development] GO:0072661 [protein targeting to plasma membrane] GO:0097108 [hedgehog family protein binding]	1381	153.9	No	>9

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.