PRG2

GENE INFORMATION

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Gene name

PRG2 (HGNC Symbol)

Synonyms

BMPG, MBP

Description

Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

Chromosome

11

Cytoband

q12.1

Chromosome location (bp)

57386794 - 57390657

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000186652 (version 78.38)

Entrez gene

5553

UniProt

P13727 (UniProt - Evidence at protein level)

neXtProt

NX_P13727

Antibodypedia

PRG2 antibodies
 

PROTEIN VIEW

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PRG2-001
 
PRG2-002
 
PRG2-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRG2-001 ENSP00000312134
ENST00000311862
P13727
Show all »
Show » Show » 222 25.2 Yes 0
PRG2-002 ENSP00000433016
ENST00000525955
P13727
Show all »
Show » Show » 222 25.2 Yes 0
PRG2-003 ENSP00000433231
ENST00000533605
P13727
Show all »
Show » Show » 211 23.9 Yes 0