TNFRSF4

GENE INFORMATION

? »

Gene name

TNFRSF4 (HGNC Symbol)

Synonyms

ACT35, CD134, OX40, TXGP1L

Description

Tumor necrosis factor receptor superfamily, member 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p36.33

Chromosome location (bp)

1211326 - 1214138

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000186827 (version 78.38)

Entrez gene

7293

UniProt

P43489 (UniProt - Evidence at protein level)

neXtProt

NX_P43489

Antibodypedia

TNFRSF4 antibodies
 

PROTEIN VIEW

? »
 
 
 
TNFRSF4-001
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TNFRSF4-001 ENSP00000368538
ENST00000379236
P43489
Show all »
Show » Show » 277 29.3 Yes 1