TLR5

GENE INFORMATION

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Gene name

TLR5 (HGNC Symbol)

Synonyms

FLJ10052, MGC126430, MGC126431, SLEB1, TIL3

Description

Toll-like receptor 5 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]

Chromosome

1

Cytoband

q41

Chromosome location (bp)

223109406 - 223143282

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000187554 (version 78.38)

Entrez gene

7100

UniProt

O60602 (UniProt - Evidence at protein level)

neXtProt

NX_O60602

Antibodypedia

TLR5 antibodies
 

PROTEIN VIEW

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TLR5-001
 
TLR5-004
 
TLR5-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TLR5-001 ENSP00000355846
ENST00000366881
O60602
Show all »
Show » Show » 858 97.8 Yes 1
TLR5-004 ENSP00000385458
ENST00000407096
B1AZ06
Show all »
Show » 21 2.2 No 0
TLR5-201 ENSP00000440643
ENST00000540964
O60602
Show all »
Show » Show » 858 97.8 Yes 1