PLA2G2A

GENE INFORMATION

? »

Gene name

PLA2G2A (HGNC Symbol)

Synonyms

PLA2B, PLA2L

Description

Phospholipase A2, group IIA (platelets, synovial fluid) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]

Chromosome

1

Cytoband

p36.13

Chromosome location (bp)

19975431 - 19980416

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000188257 (version 78.38)

Entrez gene

5320

UniProt

P14555 (UniProt - Evidence at protein level)

neXtProt

NX_P14555

Antibodypedia

PLA2G2A antibodies
 

PROTEIN VIEW

? »
 
 
 
PLA2G2A-001
 
PLA2G2A-201
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PLA2G2A-001 ENSP00000364252
ENST00000375111
P14555
Show all »
Show » Show » 144 16.1 Yes 0
PLA2G2A-201 ENSP00000383364
ENST00000400520
P14555
Show all »
Show » Show » 144 16.1 Yes 0