SLX4

GENE INFORMATION

? »

Gene name

SLX4 (HGNC Symbol)

Synonyms

BTBD12, FANCP, KIAA1784, KIAA1987

Description

SLX4 structure-specific endonuclease subunit (HGNC Symbol)

Entrez gene summary

This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.[provided by RefSeq, Jan 2011]

Chromosome

16

Cytoband

p13.3

Chromosome location (bp)

3581181 - 3611598

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000188827 (version 78.38)

Entrez gene

84464

UniProt

Q8IY92 (UniProt - Evidence at protein level)

neXtProt

NX_Q8IY92

Antibodypedia

SLX4 antibodies
 

PROTEIN VIEW

? »
 
 
 
SLX4-001
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLX4-001 ENSP00000294008
ENST00000294008
Q8IY92
Show all »
Show » Show » 1834 200 No 0