CLDN4

GENE INFORMATION

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Gene name

CLDN4 (HGNC Symbol)

Synonyms

CPE-R, CPETR, CPETR1, hCPE-R, WBSCR8

Description

Claudin 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013]

Chromosome

7

Cytoband

q11.23

Chromosome location (bp)

73799542 - 73832693

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000189143 (version 78.38)

Entrez gene

1364

UniProt

O14493 (UniProt - Evidence at protein level)

neXtProt

NX_O14493

Antibodypedia

CLDN4 antibodies
 

PROTEIN VIEW

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CLDN4-001
 
CLDN4-002
 
CLDN4-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CLDN4-001 ENSP00000388639
ENST00000431918
O14493
Show all »
Show » Show » 209 22.1 No 3
CLDN4-002 ENSP00000409544
ENST00000435050
O14493
Show all »
Show » Show » 209 22.1 No 3
CLDN4-201 ENSP00000342445
ENST00000340958
O14493
Show all »
Show » Show » 209 22.1 No 3