FHIT

GENE INFORMATION

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Gene name

FHIT (HGNC Symbol)

Synonyms

AP3Aase, FRA3B

Description

Fragile histidine triad (HGNC Symbol)

Entrez gene summary

This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]

Chromosome

3

Cytoband

p14.2

Chromosome location (bp)

59749310 - 61251459

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000189283 (version 78.38)

Entrez gene

2272

UniProt

P49789 (UniProt - Evidence at protein level)

neXtProt

NX_P49789

Antibodypedia

FHIT antibodies
 

PROTEIN VIEW

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FHIT-001
 
FHIT-002
 
FHIT-003
 
FHIT-007
 
FHIT-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FHIT-001 ENSP00000417557
ENST00000476844
P49789
Show all »
Show » Show » 147 16.9 No 0
FHIT-002 ENSP00000417480
ENST00000468189
P49789
Show all »
Show » Show » 147 16.9 No 0
FHIT-003 ENSP00000418582
ENST00000492590
P49789
Show all »
Show » Show » 147 16.9 No 0
FHIT-007 ENSP00000418596
ENST00000488467
E9PBZ0
Show all »
Show » Show » 79 9 No 0
FHIT-201 ENSP00000342087
ENST00000341848
Show » Show » 58 6.5 No 0