IARS

GENE INFORMATION

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Gene name

IARS (HGNC Symbol)

Synonyms

IARS1, ILRS

Description

Isoleucyl-tRNA synthetase (HGNC Symbol)

Entrez gene summary

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012]

Chromosome

9

Cytoband

q22.31

Chromosome location (bp)

92210207 - 92293716

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000196305 (version 78.38)

Entrez gene

3376

UniProt

P41252 (UniProt - Evidence at protein level)

neXtProt

NX_P41252

Antibodypedia

IARS antibodies
 

PROTEIN VIEW

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IARS-001
 
IARS-002
 
IARS-006
 
IARS-010
 
IARS-201
 
IARS-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IARS-001 ENSP00000364794
ENST00000375643
P41252
Show all »
Show » Show » 1262 144.5 No 0
IARS-002 ENSP00000378922
ENST00000395554
Q5TCD1
Show all »
Show » Show » 330 38.3 No 0
IARS-006 ENSP00000387603
ENST00000430417
Q5TCC9
Show all »
Show » 72 8.8 No 0
IARS-010 ENSP00000364778
ENST00000375627
Q5TCC6
Show all »
Show » 174 19.5 No 0
IARS-201 ENSP00000406448
ENST00000443024
Q5TCD1
Show all »
Show » Show » 1242 142.3 No 0
IARS-202 ENSP00000415020
ENST00000447699
J3KR24
Show all »
Show » Show » 1152 131.8 No 0