NCOR2 - Gene info - The Human Protein Atlas

NCOR2

TISSUE

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SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	NCOR2 (HGNC Symbol)
Synonyms	CTG26, SMRT, SMRTE, TNRC14, TRAC-1
Description	Nuclear receptor corepressor 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]
Chromosome	12
Cytoband	q24.31
Chromosome location (bp)	124324415 - 124567589
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196498 (version 78.38)
Entrez gene	9612
UniProt	Q9Y618 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y618
Antibodypedia	NCOR2 antibodies

PROTEIN VIEW

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NCOR2-001		NCOR2-002		NCOR2-003		NCOR2-004		NCOR2-005		NCOR2-009		NCOR2-012		NCOR2-013		NCOR2-015		NCOR2-017		NCOR2-018		NCOR2-019		NCOR2-024		NCOR2-201		NCOR2-202

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
NCOR2-001	ENSP00000400281 ENST00000429285	C9J0Q5 Show all » « Hide C9J0Q5 [Target identity:100%; Query identity:100%] Nuclear receptor corepressor 2 {ECO:0000313\|Ensembl:ENSP00000400281} C9J7T7 [Target identity:82%; Query identity:100%] Nuclear receptor corepressor 2 {ECO:0000313\|Ensembl:ENSP00000385618}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005634 [nucleus]	2504	272.8	No	0
NCOR2-002	ENSP00000384202 ENST00000404621	C9JE98 Show all » « Hide C9JE98 [Target identity:100%; Query identity:100%] Nuclear receptor corepressor 2 {ECO:0000313\|Ensembl:ENSP00000384202}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005634 [nucleus]	2458	268	No	0
NCOR2-003	ENSP00000402808 ENST00000458234	C9JQE8 Show all » « Hide C9JQE8 [Target identity:100%; Query identity:100%] Nuclear receptor corepressor 2 {ECO:0000313\|Ensembl:ENSP00000402808} C9J330 [Target identity:33%; Query identity:100%] Nuclear receptor corepressor 2 {ECO:0000313\|Ensembl:ENSP00000405367}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005634 [nucleus]	1451	160.4	No	0
NCOR2-004	ENSP00000405367 ENST00000420698	C9J330 Show all » « Hide C9J330 [Target identity:100%; Query identity:100%] Nuclear receptor corepressor 2 {ECO:0000313\|Ensembl:ENSP00000405367}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003682 [chromatin binding]	493	58	No	0
NCOR2-005	ENSP00000384018 ENST00000405201	C9JFD3 Show all » « Hide C9JFD3 [Target identity:100%; Query identity:100%] Nuclear receptor corepressor 2 {ECO:0000313\|Ensembl:ENSP00000384018} A0A024RBS3 [Target identity:100%; Query identity:99%] Nuclear receptor co-repressor 2, isoform CRA_c {ECO:0000313\|EMBL:EAW98452.1} C9J330 [Target identity:19%; Query identity:100%] Nuclear receptor corepressor 2 {ECO:0000313\|Ensembl:ENSP00000405367}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000118 [histone deacetylase complex] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000785 [chromatin] GO:0001012 [RNA polymerase II regulatory region DNA binding] GO:0001701 [in utero embryonic development] GO:0003007 [heart morphogenesis] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003714 [transcription corepressor activity] GO:0005112 [Notch binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007219 [Notch signaling pathway] GO:0007595 [lactation] GO:0010243 [response to organonitrogen compound] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016363 [nuclear matrix] GO:0016604 [nuclear body] GO:0016922 [ligand-dependent nuclear receptor binding] GO:0017053 [transcriptional repressor complex] GO:0021537 [telencephalon development] GO:0021846 [cell proliferation in forebrain] GO:0030900 [forebrain development] GO:0032355 [response to estradiol] GO:0032403 [protein complex binding] GO:0035259 [glucocorticoid receptor binding] GO:0042593 [glucose homeostasis] GO:0042698 [ovulation cycle] GO:0042826 [histone deacetylase binding] GO:0042974 [retinoic acid receptor binding] GO:0043565 [sequence-specific DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045599 [negative regulation of fat cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046965 [retinoid X receptor binding] GO:0047485 [protein N-terminus binding] GO:0050872 [white fat cell differentiation] GO:0060206 [estrous cycle phase] GO:0060509 [Type I pneumocyte differentiation] GO:0072365 [regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter]	2514	273.7	No	0
NCOR2-009	ENSP00000408247 ENST00000448614	C9JNV9 Show all » « Hide C9JNV9 [Target identity:100%; Query identity:100%] Nuclear receptor corepressor 2 {ECO:0000313\|Ensembl:ENSP00000408247}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003682 [chromatin binding]	162	17.7	No	0
NCOR2-012	ENSP00000400687 ENST00000453428		Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		225	24.3	No	0
NCOR2-013	ENSP00000396044 ENST00000440187		Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		156	16.4	No	0
NCOR2-015	ENSP00000398963 ENST00000440337		Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		134	14.5	No	0
NCOR2-017	ENSP00000391389 ENST00000418829		Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		129	13.6	No	0
NCOR2-018	ENSP00000407357 ENST00000413172		Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		132	13.6	No	0
NCOR2-019	ENSP00000403034 ENST00000448008	H7C1Y3 Show all » « Hide H7C1Y3 [Target identity:100%; Query identity:100%] Nuclear receptor corepressor 2 {ECO:0000313\|Ensembl:ENSP00000403034}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		245	29.2	No	0
NCOR2-024	ENSP00000443689 ENST00000542927		Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		275	32.5	No	0
NCOR2-201	ENSP00000348551 ENST00000356219	Q9Y618 Show all » « Hide Q9Y618 [Direct mapping] Nuclear receptor corepressor 2	Show » « Hide Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003714 [transcription corepressor activity] GO:0005112 [Notch binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007219 [Notch signaling pathway] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016363 [nuclear matrix] GO:0016604 [nuclear body] GO:0017053 [transcriptional repressor complex] GO:0042826 [histone deacetylase binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0047485 [protein N-terminus binding] GO:0072365 [regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter]	2079	222.7	No	0
NCOR2-202	ENSP00000385618 ENST00000404121		Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003682 [chromatin binding]	2062	221	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.