HBG2

GENE INFORMATION

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Gene name

HBG2 (HGNC Symbol)

Synonyms

HBG-T1

Description

Hemoglobin, gamma G (HGNC Symbol)

Entrez gene summary

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'- epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p15.4

Chromosome location (bp)

5248274 - 5645789

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000196565 (version 78.38)

Entrez gene

3048

UniProt

P69892 (UniProt - Evidence at protein level)

neXtProt

NX_P69892

Antibodypedia

HBG2 antibodies
 

PROTEIN VIEW

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HBG2-001
 
HBG2-004
 
HBG2-201
 
HBG2-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HBG2-001 ENSP00000369609
ENST00000380259
P69892
Show all »
Show » Show » 147 16.1 No 0
HBG2-004 ENSP00000369602
ENST00000380252
E9PBW4
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Show » Show » 137 15.3 No 0
HBG2-201 ENSP00000338082
ENST00000336906
P69892
Show all »
Show » Show » 147 16.1 No 0
HBG2-202 ENSP00000479637
ENST00000620888
Q14474
Show all »
Show » Show » 147 16.1 No 0