MKL1

GENE INFORMATION

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Gene name

MKL1 (HGNC Symbol)

Synonyms

BSAC, KIAA1438, MAL, MRTF-A

Description

Megakaryoblastic leukemia (translocation) 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Chromosome

22

Cytoband

Chromosome location (bp)

40410281 - 40636702

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000196588 (version 78.38)

Entrez gene

57591

UniProt

Q969V6 (UniProt - Evidence at protein level)

neXtProt

NX_Q969V6

Antibodypedia

MKL1 antibodies
 

PROTEIN VIEW

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MKL1-001
 
MKL1-002
 
MKL1-003
 
MKL1-006
 
MKL1-009
 
MKL1-201
 
MKL1-202
 
MKL1-203
 
MKL1-204
 
MKL1-205
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MKL1-001 ENSP00000347847
ENST00000355630
Q969V6
Show all »
Show » Show » 931 98.9 No 0
MKL1-002 ENSP00000385584
ENST00000402042
B0QY83
Show all »
Show » Show » 881 93.6 No 0
MKL1-003 ENSP00000385835
ENST00000407029
Q969V6
Show all »
Show » Show » 931 98.9 No 0
MKL1-006 ENSP00000398478
ENST00000422851
B0QY74
Show all »
Show » Show » 73 8.8 No 0
MKL1-009 ENSP00000385076
ENST00000402630
B0QY84
Show all »
Show » Show » 161 18.4 No 0
MKL1-201 ENSP00000379861
ENST00000396617
E7ER32
Show all »
Show » Show » 798 85.1 No 0
MKL1-202 ENSP00000484786
ENST00000614754
Show » 799 85.2 No 0
MKL1-203 ENSP00000479510
ENST00000618196
W0Z7M9
Show all »
Show » Show » 966 103 No 0
MKL1-204 ENSP00000484628
ENST00000618417
Q29R68
Show all »
Show » 85 9.1 No 0
MKL1-205 ENSP00000478420
ENST00000620651
Q29R68
Show all »
Show » 882 93.7 No 0