HRH1

GENE INFORMATION

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Gene name

HRH1

Synonyms

Description

Histamine receptor H1 (HGNC Symbol)

Entrez gene summary

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015]

Chromosome

3

Cytoband

p25.3

Chromosome location (bp)

11137093 - 11263557

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000196639 (version 78.38)

Entrez gene

3269

UniProt

P35367 (UniProt - Evidence at protein level)

neXtProt

NX_P35367

Antibodypedia

HRH1 antibodies
 

PROTEIN VIEW

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HRH1-001
 
HRH1-002
 
HRH1-003
 
HRH1-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HRH1-001 ENSP00000380247
ENST00000397056
P35367
Show all »
Show » Show » 487 55.8 No 7
HRH1-002 ENSP00000406705
ENST00000438284
P35367
Show all »
Show » Show » 487 55.8 No 7
HRH1-003 ENSP00000397028
ENST00000431010
P35367
Show all »
Show » Show » 487 55.8 No 7
HRH1-004 ENSP00000392383
ENST00000413416
Show » 12 1.3 No 0