DIO3

GENE INFORMATION

? »

Gene name

DIO3 (HGNC Symbol)

Synonyms

TXDI3

Description

Deiodinase, iodothyronine, type III (HGNC Symbol)

Entrez gene summary

The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q32.31

Chromosome location (bp)

101561351 - 101563452

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000197406 (version 78.38)

Entrez gene

1735

UniProt

P55073 (UniProt - Evidence at protein level)

neXtProt

NX_P55073

Antibodypedia

DIO3 antibodies
 

PROTEIN VIEW

? »
 
 
 
DIO3-001
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DIO3-001 ENSP00000427336
ENST00000510508
P55073
Show all »
Show » Show » 304 33.9 No 1