MYO1C - Gene info - The Human Protein Atlas

MYO1C

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TISSUE

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SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	MYO1C (HGNC Symbol)
Synonyms	myr2
Description	Myosin IC (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p13.3
Chromosome location (bp)	1464098 - 1492812
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000197879 (version 78.38)
Entrez gene	4641
UniProt	O00159 (UniProt - Evidence at protein level)
neXtProt	NX_O00159
Antibodypedia	MYO1C antibodies

PROTEIN VIEW

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MYO1C-001		MYO1C-002		MYO1C-003		MYO1C-005		MYO1C-006		MYO1C-007		MYO1C-008		MYO1C-009		MYO1C-010		MYO1C-011		MYO1C-201

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
MYO1C-001	ENSP00000352834 ENST00000359786	O00159 Show all » « Hide O00159 [Direct mapping] Unconventional myosin-Ic I3L204 [Target identity:25%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000459271} I3L3Y6 [Target identity:15%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000460831} I3L4D4 [Target identity:15%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000461175} I3L168 [Target identity:12%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000458610} I3L3F5 [Target identity:12%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000460415}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003774 [motor activity] GO:0003779 [actin binding] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005643 [nuclear pore] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005902 [microvillus] GO:0005903 [brush border] GO:0006200 [ATP catabolic process] GO:0006605 [protein targeting] GO:0006612 [protein targeting to membrane] GO:0006810 [transport] GO:0008022 [protein C-terminus binding] GO:0008152 [metabolic process] GO:0009925 [basal plasma membrane] GO:0016020 [membrane] GO:0016328 [lateral plasma membrane] GO:0016459 [myosin complex] GO:0016461 [unconventional myosin complex] GO:0030335 [positive regulation of cell migration] GO:0030898 [actin-dependent ATPase activity] GO:0031410 [cytoplasmic vesicle] GO:0031941 [filamentous actin] GO:0032420 [stereocilium] GO:0038089 [positive regulation of cell migration by vascular endothelial growth factor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045160 [myosin I complex] GO:0051028 [mRNA transport] GO:0061024 [membrane organization] GO:0070062 [extracellular vesicular exosome] GO:0090314 [positive regulation of protein targeting to membrane] GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway] GO:2000810 [regulation of tight junction assembly]	1063	121.7	No	0
MYO1C-002	ENSP00000459174 ENST00000575158	O00159 Show all » « Hide O00159 [Direct mapping] Unconventional myosin-Ic I3L204 [Target identity:25%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000459271} I3L3Y6 [Target identity:16%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000460831} I3L4D4 [Target identity:15%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000461175} I3L168 [Target identity:13%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000458610} I3L3F5 [Target identity:13%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000460415}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003774 [motor activity] GO:0003779 [actin binding] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005643 [nuclear pore] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005902 [microvillus] GO:0006605 [protein targeting] GO:0006612 [protein targeting to membrane] GO:0008152 [metabolic process] GO:0009925 [basal plasma membrane] GO:0016020 [membrane] GO:0016328 [lateral plasma membrane] GO:0016459 [myosin complex] GO:0016461 [unconventional myosin complex] GO:0030335 [positive regulation of cell migration] GO:0031410 [cytoplasmic vesicle] GO:0031941 [filamentous actin] GO:0038089 [positive regulation of cell migration by vascular endothelial growth factor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0051028 [mRNA transport] GO:0061024 [membrane organization] GO:0070062 [extracellular vesicular exosome] GO:0090314 [positive regulation of protein targeting to membrane] GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway] GO:2000810 [regulation of tight junction assembly]	1028	117.9	No	0
MYO1C-003	ENSP00000437685 ENST00000545534	F5H6E2 Show all » « Hide F5H6E2 [Target identity:100%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000437685} I3L204 [Target identity:25%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000459271} I3L3Y6 [Target identity:16%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000460831} I3L4D4 [Target identity:15%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000461175} I3L3F5 [Target identity:13%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000460415} I3L168 [Target identity:12%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000458610}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003774 [motor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0016459 [myosin complex]	1039	119	No	0
MYO1C-005	ENSP00000461175 ENST00000574790	I3L4D4 Show all » « Hide I3L4D4 [Target identity:100%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000461175} I3L3F5 [Target identity:83%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000460415} I3L168 [Target identity:81%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000458610}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003774 [motor activity] GO:0005524 [ATP binding] GO:0008152 [metabolic process] GO:0016459 [myosin complex]	164	18.7	No	0
MYO1C-006	ENSP00000460415 ENST00000575335	I3L3F5 Show all » « Hide I3L3F5 [Target identity:99%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000460415} I3L168 [Target identity:97%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000458610}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003774 [motor activity] GO:0005524 [ATP binding] GO:0008152 [metabolic process] GO:0016459 [myosin complex]	138	15.9	No	0
MYO1C-007	ENSP00000459271 ENST00000570984	I3L204 Show all » « Hide I3L204 [Target identity:100%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000459271} I3L3Y6 [Target identity:63%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000460831} I3L4D4 [Target identity:61%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000461175} I3L3F5 [Target identity:51%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000460415} I3L168 [Target identity:50%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000458610}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003774 [motor activity] GO:0005524 [ATP binding] GO:0008152 [metabolic process] GO:0016459 [myosin complex]	267	30.7	No	0
MYO1C-008	ENSP00000458610 ENST00000571715	I3L168 Show all » « Hide I3L168 [Target identity:100%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000458610}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003774 [motor activity] GO:0005524 [ATP binding] GO:0008152 [metabolic process] GO:0016459 [myosin complex]	134	15.4	No	0
MYO1C-009	ENSP00000460831 ENST00000573853	I3L3Y6 Show all » « Hide I3L3Y6 [Target identity:100%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000460831} I3L4D4 [Target identity:96%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000461175} I3L3F5 [Target identity:80%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000460415} I3L168 [Target identity:78%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000458610}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003774 [motor activity] GO:0005524 [ATP binding] GO:0008152 [metabolic process] GO:0016459 [myosin complex]	170	19.5	No	0
MYO1C-010	ENSP00000412197 ENST00000438665	O00159 Show all » « Hide O00159 [Direct mapping] Unconventional myosin-Ic I3L204 [Target identity:25%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000459271} I3L3Y6 [Target identity:16%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000460831} I3L4D4 [Target identity:15%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000461175} I3L3F5 [Target identity:13%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000460415} I3L168 [Target identity:12%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000458610}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003774 [motor activity] GO:0003779 [actin binding] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005643 [nuclear pore] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005902 [microvillus] GO:0006605 [protein targeting] GO:0006612 [protein targeting to membrane] GO:0008152 [metabolic process] GO:0009925 [basal plasma membrane] GO:0016020 [membrane] GO:0016328 [lateral plasma membrane] GO:0016459 [myosin complex] GO:0016461 [unconventional myosin complex] GO:0030335 [positive regulation of cell migration] GO:0031410 [cytoplasmic vesicle] GO:0031941 [filamentous actin] GO:0038089 [positive regulation of cell migration by vascular endothelial growth factor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0051028 [mRNA transport] GO:0061024 [membrane organization] GO:0070062 [extracellular vesicular exosome] GO:0090314 [positive regulation of protein targeting to membrane] GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway] GO:2000810 [regulation of tight junction assembly]	1044	119.6	No	0
MYO1C-011	ENSP00000461682 ENST00000570490	I3L501 Show all » « Hide I3L501 [Target identity:99%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000461682} I3L3F5 [Target identity:81%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000460415} I3L168 [Target identity:79%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000458610}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003774 [motor activity] GO:0005524 [ATP binding] GO:0008152 [metabolic process] GO:0016459 [myosin complex]	169	19.2	No	0
MYO1C-201	ENSP00000354283 ENST00000361007	O00159 Show all » « Hide O00159 [Direct mapping] Unconventional myosin-Ic I3L204 [Target identity:25%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000459271} I3L3Y6 [Target identity:16%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000460831} I3L4D4 [Target identity:15%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000461175} I3L168 [Target identity:13%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000458610} I3L3F5 [Target identity:13%; Query identity:100%] Unconventional myosin-Ic {ECO:0000313\|Ensembl:ENSP00000460415}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003774 [motor activity] GO:0003779 [actin binding] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005643 [nuclear pore] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005902 [microvillus] GO:0006605 [protein targeting] GO:0006612 [protein targeting to membrane] GO:0008152 [metabolic process] GO:0009925 [basal plasma membrane] GO:0016020 [membrane] GO:0016328 [lateral plasma membrane] GO:0016459 [myosin complex] GO:0016461 [unconventional myosin complex] GO:0030335 [positive regulation of cell migration] GO:0031410 [cytoplasmic vesicle] GO:0031941 [filamentous actin] GO:0038089 [positive regulation of cell migration by vascular endothelial growth factor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0051028 [mRNA transport] GO:0061024 [membrane organization] GO:0070062 [extracellular vesicular exosome] GO:0090314 [positive regulation of protein targeting to membrane] GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway] GO:2000810 [regulation of tight junction assembly]	1028	117.9	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.