CNOT7

GENE INFORMATION

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Gene name

CNOT7 (HGNC Symbol)

Synonyms

CAF1

Description

CCR4-NOT transcription complex, subunit 7 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]

Chromosome

8

Cytoband

p22

Chromosome location (bp)

17224964 - 17246878

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198791 (version 78.38)

Entrez gene

29883

UniProt

Q9UIV1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UIV1

Antibodypedia

CNOT7 antibodies
 

PROTEIN VIEW

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CNOT7-001
 
CNOT7-002
 
CNOT7-007
 
CNOT7-008
 
CNOT7-011
 
CNOT7-012
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CNOT7-001 ENSP00000355279
ENST00000361272
Q9UIV1
Show all »
Show » Show » 285 32.7 No 0
CNOT7-002 ENSP00000429093
ENST00000523917
Q9UIV1
Show all »
Show » Show » 244 28.2 No 0
CNOT7-007 ENSP00000430160
ENST00000524358
E5RGH2
Show all »
Show » Show » 147 17 No 0
CNOT7-008 ENSP00000429079
ENST00000520178
E5RJE0
Show all »
Show » Show » 41 4.9 No 0
CNOT7-011 ENSP00000428147
ENST00000519918
Show » Show » 208 24.1 No 0
CNOT7-012 ENSP00000430263
ENST00000518541
Show » Show » 91 10.4 No 0