CES1

GENE INFORMATION

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Gene name

CES1 (HGNC Symbol)

Synonyms

CEH, CES1A1, CES1A2, CES2, HMSE, HMSE1, SES1

Description

Carboxylesterase 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Chromosome

16

Cytoband

q12.2

Chromosome location (bp)

55802851 - 55833337

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198848 (version 78.38)

Entrez gene

1066

UniProt

P23141 (UniProt - Evidence at protein level)

neXtProt

NX_P23141

Antibodypedia

CES1 antibodies
 

PROTEIN VIEW

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CES1-001
 
CES1-002
 
CES1-004
 
CES1-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CES1-001 ENSP00000390492
ENST00000422046
P23141
Show all »
Show » Show » 566 62.4 Yes 0
CES1-002 ENSP00000353720
ENST00000360526
P23141
Show all »
Show » Show » 568 62.6 Yes 0
CES1-004 ENSP00000355193
ENST00000361503
P23141
Show all »
Show » Show » 567 62.5 Yes 0
CES1-010 ENSP00000455959
ENST00000563241
H3BQV8
Show all »
Show » 131 14.9 No 0