TGM2

GENE INFORMATION

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Gene name

TGM2 (HGNC Symbol)

Synonyms

TGC

Description

Transglutaminase 2 (HGNC Symbol)

Entrez gene summary

Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

q11.23

Chromosome location (bp)

38127387 - 38166578

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198959 (version 78.38)

Entrez gene

7052

UniProt

P21980 (UniProt - Evidence at protein level)

neXtProt

NX_P21980

Antibodypedia

TGM2 antibodies
 

PROTEIN VIEW

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TGM2-002
 
TGM2-003
 
TGM2-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TGM2-002 ENSP00000355330
ENST00000361475
P21980
Show all »
Show » Show » 687 77.3 No 0
TGM2-003 ENSP00000387642
ENST00000453095
A2A2A0
Show all »
Show » Show » 160 17.9 No 0
TGM2-004 ENSP00000362502
ENST00000373403
A2A299
Show all »
Show » Show » 281 31.6 No 0