FCGR3A

GENE INFORMATION

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Gene name

FCGR3A (HGNC Symbol)

Synonyms

CD16, CD16a, FCG3, FCGR3

Description

Fc fragment of IgG, low affinity IIIa, receptor (CD16a) (HGNC Symbol)

Entrez gene summary

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q23.3

Chromosome location (bp)

161541759 - 161550737

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000203747 (version 78.38)

Entrez gene

2214

UniProt

P08637 (UniProt - Evidence at protein level)

neXtProt

NX_P08637

Antibodypedia

FCGR3A antibodies
 

PROTEIN VIEW

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FCGR3A-001
 
FCGR3A-003
 
FCGR3A-004
 
FCGR3A-005
 
FCGR3A-201
 
FCGR3A-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FCGR3A-001 ENSP00000356946
ENST00000367969
M9MML0
Show all »
Show » Show » 290 32.7 No 1
FCGR3A-003 ENSP00000356944
ENST00000367967
P08637
Show all »
Show » Show » 254 29.1 Yes 1
FCGR3A-004 ENSP00000396567
ENST00000442336
C9JC71
Show all »
Show » Show » 105 11.8 Yes 0
FCGR3A-005 ENSP00000410180
ENST00000426740
C9JC71
Show all »
Show » Show » 271 30.7 No 1
FCGR3A-201 ENSP00000416607
ENST00000436743
P08637
Show all »
Show » Show » 254 29.1 Yes 1
FCGR3A-202 ENSP00000392047
ENST00000443193
P08637
Show all »
Show » Show » 254 29.1 Yes 1