SPRR2E

GENE INFORMATION

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Gene name

SPRR2E

Synonyms

Description

Small proline-rich protein 2E (HGNC Symbol)

Entrez gene summary

This gene encodes a member of a family of small proline-rich proteins clustered in the epidermal differentiation complex on chromosome 1q21. The encoded protein, along with other family members, is a component of the cornified cell envelope that forms beneath the plasma membrane in terminally differentiated stratified squamous epithelia. This envelope serves as a barrier against extracellular and environmental factors. The seven SPRR2 genes (A-G) appear to have been homogenized by gene conversion compared to others in the cluster that exhibit greater differences in protein structure. [provided by RefSeq, Feb 2014]

Chromosome

1

Cytoband

q21.3

Chromosome location (bp)

153093135 - 153106184

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000203785 (version 78.38)

Entrez gene

6704

UniProt

P22531 (UniProt - Evidence at transcript level)

neXtProt

NX_P22531

Antibodypedia

SPRR2E antibodies
 

PROTEIN VIEW

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SPRR2E-001
 
SPRR2E-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SPRR2E-001 ENSP00000357740
ENST00000368751
P22531
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Show » Show » 72 7.9 No 0
SPRR2E-002 ENSP00000357739
ENST00000368750
P22531
Show all »
Show » Show » 72 7.9 No 0