|
|
GENE INFORMATION
? »
|
The gene information section lists the gene name (HUGO Gene Nomenclature Committee ( HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version.
The Entrez gene identifier for the gene is also given. If any of the protein products of
the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the
neXtProt databases for these proteins are displayed.
There is also a link to the Antibodypedia portal where validation data for antibodies produced by other suppliers
against this gene can be found.
|
Gene name |
TAP2 (HGNC Symbol) |
Synonyms |
ABCB3, D6S217E, PSF2, RING11 |
Description |
Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) (HGNC Symbol) |
Entrez gene summary |
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Feb 2014] |
Chromosome |
6 |
Cytoband |
p21.32 |
Chromosome location (bp) |
32821833 - 32838780 |
Protein evidence |
Evidence at protein level (all genes) |
Ensembl |
ENSG00000204267 (version 78.38) |
Entrez gene |
6891 |
UniProt |
Q03519 (UniProt - Evidence at protein level) |
neXtProt |
NX_Q03519 |
Antibodypedia |
TAP2 antibodies |
|
| |
|
|
PROTEIN VIEW
? »
|
The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues
(HsID 10) or 50 aa residues (HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS,
SignalP 4.0, and
Phobius
(turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green.
Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed
( read more), and at the bottom of the protein view is the protein scale.
|
|
|
| |
|
|
PROTEIN INFORMATION
? »
|
The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant.
The data in the UniProt column can be expanded to show links to all matching
UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors
SPOCTOPUS,
SignalP 4.0, and
Phobius) and the number of predicted transmembrane region(s) (according to
MDM) are also reported.
|
Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length
(aa) |
Molecular mass
(kDa) |
Signal peptide
(predicted) |
Transmembrane regions
(predicted)
|
| TAP2-001 |
ENSP00000364032
ENST00000374897
|
Q03519
Show all »
« Hide
Q03519 [Direct mapping]Antigen peptide transporter 2 Q5JNW1 [Target identity:100%; Query identity:100%]TAP2 {ECO:0000313|EMBL:AHW47924.1}; Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) {ECO:0000313|EMBL:AAP88908.1}; Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), isoform CRA_b {ECO:0000313|EMBL:EAX03643.1}; cDNA FLJ77215, highly similar to Homo sapiens transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), mRNA {ECO:0000313|EMBL:BAF85652.1} B6VNV2 [Target identity:30%; Query identity:100%]Truncated antigen peptide transporter 2 {ECO:0000313|EMBL:CAR92541.1}
|
Show »
« Hide
Transporters
Primary Active Transporters
Predicted membrane proteins
Prediction method-based
Membrane proteins predicted by MDM
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
# TM segments-based
8TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
|
Show »
« Hide
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0002481 [antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent] GO:0002485 [antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent] GO:0002489 [antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent] GO:0002591 [positive regulation of antigen processing and presentation of peptide antigen via MHC class I] GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006200 [ATP catabolic process] GO:0006810 [transport] GO:0015197 [peptide transporter activity] GO:0015433 [peptide antigen-transporting ATPase activity] GO:0015440 [peptide-transporting ATPase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0019060 [intracellular transport of viral protein in host cell] GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I] GO:0023029 [MHC class Ib protein binding] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0042287 [MHC protein binding] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0042825 [TAP complex] GO:0046967 [cytosol to ER transport] GO:0046968 [peptide antigen transport] GO:0046978 [TAP1 binding] GO:0046980 [tapasin binding] GO:0055085 [transmembrane transport]
|
686 |
75.7 |
No |
8 |
| TAP2-002 |
ENSP00000364034
ENST00000374899
|
Q03519
Show all »
« Hide
Q03519 [Direct mapping]Antigen peptide transporter 2 Q9UP03 [Target identity:100%; Query identity:100%]Transporter 2 isoform {ECO:0000313|EMBL:AAD31384.1}; Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), isoform CRA_a {ECO:0000313|EMBL:EAX03642.1} B6VNV2 [Target identity:32%; Query identity:100%]Truncated antigen peptide transporter 2 {ECO:0000313|EMBL:CAR92541.1}
|
Show »
« Hide
Transporters
Primary Active Transporters
Predicted membrane proteins
Prediction method-based
Membrane proteins predicted by MDM
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
# TM segments-based
8TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
|
Show »
« Hide
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0002481 [antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent] GO:0002485 [antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent] GO:0002489 [antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent] GO:0002591 [positive regulation of antigen processing and presentation of peptide antigen via MHC class I] GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006200 [ATP catabolic process] GO:0006810 [transport] GO:0015197 [peptide transporter activity] GO:0015433 [peptide antigen-transporting ATPase activity] GO:0015440 [peptide-transporting ATPase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0019060 [intracellular transport of viral protein in host cell] GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I] GO:0023029 [MHC class Ib protein binding] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0042287 [MHC protein binding] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0042825 [TAP complex] GO:0046967 [cytosol to ER transport] GO:0046968 [peptide antigen transport] GO:0046978 [TAP1 binding] GO:0046980 [tapasin binding] GO:0055085 [transmembrane transport]
|
653 |
72 |
No |
8 |
| TAP2-201 |
ENSP00000481712
ENST00000620123
|
Q5JNW1
Show all »
« Hide
Q5JNW1 [Target identity:97%; Query identity:100%]TAP2 {ECO:0000313|EMBL:AHW47924.1}; Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) {ECO:0000313|EMBL:AAP88908.1}; Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), isoform CRA_b {ECO:0000313|EMBL:EAX03643.1}; cDNA FLJ77215, highly similar to Homo sapiens transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), mRNA {ECO:0000313|EMBL:BAF85652.1} B6VNV2 [Target identity:29%; Query identity:100%]Truncated antigen peptide transporter 2 {ECO:0000313|EMBL:CAR92541.1}
|
Show »
« Hide
Predicted membrane proteins
Prediction method-based
Membrane proteins predicted by MDM
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
# TM segments-based
8TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
|
Show »
« Hide
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0002481 [antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent] GO:0002485 [antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent] GO:0002489 [antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent] GO:0002591 [positive regulation of antigen processing and presentation of peptide antigen via MHC class I] GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006200 [ATP catabolic process] GO:0006810 [transport] GO:0015197 [peptide transporter activity] GO:0015433 [peptide antigen-transporting ATPase activity] GO:0015440 [peptide-transporting ATPase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0019060 [intracellular transport of viral protein in host cell] GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I] GO:0023029 [MHC class Ib protein binding] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0042287 [MHC protein binding] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0042825 [TAP complex] GO:0046967 [cytosol to ER transport] GO:0046968 [peptide antigen transport] GO:0046978 [TAP1 binding] GO:0046980 [tapasin binding] GO:0055085 [transmembrane transport]
|
702 |
77.6 |
No |
8 |
|
|
|
|
|
|
