LILRB3

GENE INFORMATION

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Gene name

LILRB3 (HGNC Symbol)

Synonyms

CD85a, HL9, ILT5, LIR-3, LIR3

Description

Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 (HGNC Symbol)

Entrez gene summary

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.42

Chromosome location (bp)

54216278 - 54223506

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000204577 (version 78.38)

Entrez gene

11025

UniProt

O75022 (UniProt - Evidence at transcript level)

neXtProt

NX_O75022

Antibodypedia

LILRB3 antibodies
 

PROTEIN VIEW

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LILRB3-001
 
LILRB3-005
 
LILRB3-008
 
LILRB3-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LILRB3-001 ENSP00000375630
ENST00000391750
O75022
Show all »
Show » Show » 631 69.4 Yes 1
LILRB3-005 ENSP00000388199
ENST00000445347
Show » Show » 158 17.4 Yes 0
LILRB3-008 ENSP00000345184
ENST00000346401
Show » Show » 643 70.6 Yes 1
LILRB3-009 ENSP00000245620
ENST00000245620
O75022
Show all »
Show » Show » 632 69.6 Yes 1