CD177

GENE INFORMATION

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Gene name

CD177 (HGNC Symbol)

Synonyms

HNA2A, NB1, PRV1

Description

CD177 molecule (HGNC Symbol)

Entrez gene summary

This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014]

Chromosome

19

Cytoband

q13.31

Chromosome location (bp)

43353659 - 43363172

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000204936 (version 78.38)

Entrez gene

57126

UniProt

neXtProt

Antibodypedia

CD177 antibodies
 

PROTEIN VIEW

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CD177-001
 
CD177-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD177-001 ENSP00000479536
ENST00000618265
Show » 437 46.4 Yes 0
CD177-002 ENSP00000483817
ENST00000607855
Show » 139 15.1 Yes 0