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GENE INFORMATION
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The gene information section lists the gene name (HUGO Gene Nomenclature Committee ( HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version.
The Entrez gene identifier for the gene is also given. If any of the protein products of
the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the
neXtProt databases for these proteins are displayed.
There is also a link to the Antibodypedia portal where validation data for antibodies produced by other suppliers
against this gene can be found.
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Gene name |
TMSB4X (HGNC Symbol) |
Synonyms |
TB4X, TMSB4 |
Description |
Thymosin beta 4, X-linked (HGNC Symbol) |
Entrez gene summary |
This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008] |
Chromosome |
X |
Cytoband |
p22.2 |
Chromosome location (bp) |
12975108 - 12977227 |
Protein evidence |
Evidence at protein level (all genes) |
Ensembl |
ENSG00000205542 (version 78.38) |
Entrez gene |
7114 |
UniProt |
P62328 (UniProt - Evidence at protein level) |
neXtProt |
NX_P62328 |
Antibodypedia |
TMSB4X antibodies |
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PROTEIN VIEW
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The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues
(HsID 10) or 50 aa residues (HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS,
SignalP 4.0, and
Phobius
(turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green.
Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed
( read more), and at the bottom of the protein view is the protein scale.
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PROTEIN INFORMATION
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The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant.
The data in the UniProt column can be expanded to show links to all matching
UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors
SPOCTOPUS,
SignalP 4.0, and
Phobius) and the number of predicted transmembrane region(s) (according to
MDM) are also reported.
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Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length (aa) |
Molecular mass (kDa) |
Signal peptide (predicted) |
Transmembrane regions (predicted)
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TMSB4X-001 |
ENSP00000370009
ENST00000380635
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P62328 Show all »
« Hide
P62328 [Direct mapping]Thymosin beta-4 Hematopoietic system regulatory peptide A2VCK8 [Target identity:100%; Query identity:100%]Thymosin beta 4, X-linked {ECO:0000313|EMBL:AAI28103.1}; Thymosin, beta 4, X-linked, isoform CRA_a {ECO:0000313|EMBL:EAW98810.1}; cDNA, FLJ92006, Homo sapiens thymosin, beta 4, X chromosome (TMSB4X), mRNA {ECO:0000313|EMBL:BAG34690.1} Q0P5T0 [Target identity:100%; Query identity:69%]TMSB4X protein {ECO:0000313|EMBL:AAH64954.1} Q0P5U7 [Target identity:100%; Query identity:67%]TMSB4X protein {ECO:0000313|EMBL:AAH61586.1} Q0P5P4 [Target identity:100%; Query identity:63%]TMSB4X protein {ECO:0000313|EMBL:AAH92437.1} Q0P5Q0 [Target identity:100%; Query identity:63%]TMSB4X protein {ECO:0000313|EMBL:AAH83509.1} Q0P5N8 [Target identity:100%; Query identity:62%]TMSB4X protein {ECO:0000313|EMBL:AAI04667.1}
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Predicted intracellular proteins Plasma proteins Cytoskeleton related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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44 |
5.1 |
No |
0 |
TMSB4X-002 |
ENSP00000414376
ENST00000451311
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P62328 Show all »
« Hide
P62328 [Direct mapping]Thymosin beta-4 Hematopoietic system regulatory peptide A2VCK8 [Target identity:100%; Query identity:100%]Thymosin beta 4, X-linked {ECO:0000313|EMBL:AAI28103.1}; Thymosin, beta 4, X-linked, isoform CRA_a {ECO:0000313|EMBL:EAW98810.1}; cDNA, FLJ92006, Homo sapiens thymosin, beta 4, X chromosome (TMSB4X), mRNA {ECO:0000313|EMBL:BAG34690.1} Q0P5T0 [Target identity:100%; Query identity:69%]TMSB4X protein {ECO:0000313|EMBL:AAH64954.1} Q0P5U7 [Target identity:100%; Query identity:67%]TMSB4X protein {ECO:0000313|EMBL:AAH61586.1} Q0P5P4 [Target identity:100%; Query identity:63%]TMSB4X protein {ECO:0000313|EMBL:AAH92437.1} Q0P5Q0 [Target identity:100%; Query identity:63%]TMSB4X protein {ECO:0000313|EMBL:AAH83509.1} Q0P5N8 [Target identity:100%; Query identity:62%]TMSB4X protein {ECO:0000313|EMBL:AAI04667.1}
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Predicted intracellular proteins Plasma proteins Cytoskeleton related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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44 |
5.1 |
No |
0 |
TMSB4X-003 |
ENSP00000370010
ENST00000380636
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P62328 Show all »
« Hide
P62328 [Direct mapping]Thymosin beta-4 Hematopoietic system regulatory peptide A2VCK8 [Target identity:100%; Query identity:100%]Thymosin beta 4, X-linked {ECO:0000313|EMBL:AAI28103.1}; Thymosin, beta 4, X-linked, isoform CRA_a {ECO:0000313|EMBL:EAW98810.1}; cDNA, FLJ92006, Homo sapiens thymosin, beta 4, X chromosome (TMSB4X), mRNA {ECO:0000313|EMBL:BAG34690.1} Q0P5T0 [Target identity:100%; Query identity:69%]TMSB4X protein {ECO:0000313|EMBL:AAH64954.1} Q0P5U7 [Target identity:100%; Query identity:67%]TMSB4X protein {ECO:0000313|EMBL:AAH61586.1} Q0P5P4 [Target identity:100%; Query identity:63%]TMSB4X protein {ECO:0000313|EMBL:AAH92437.1} Q0P5Q0 [Target identity:100%; Query identity:63%]TMSB4X protein {ECO:0000313|EMBL:AAH83509.1} Q0P5N8 [Target identity:100%; Query identity:62%]TMSB4X protein {ECO:0000313|EMBL:AAI04667.1}
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Predicted intracellular proteins Plasma proteins Cytoskeleton related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
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44 |
5.1 |
No |
0 |
TMSB4X-004 |
ENSP00000370007
ENST00000380633
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P62328 Show all »
« Hide
P62328 [Direct mapping]Thymosin beta-4 Hematopoietic system regulatory peptide A2VCK8 [Target identity:100%; Query identity:100%]Thymosin beta 4, X-linked {ECO:0000313|EMBL:AAI28103.1}; Thymosin, beta 4, X-linked, isoform CRA_a {ECO:0000313|EMBL:EAW98810.1}; cDNA, FLJ92006, Homo sapiens thymosin, beta 4, X chromosome (TMSB4X), mRNA {ECO:0000313|EMBL:BAG34690.1} Q0P5T0 [Target identity:100%; Query identity:69%]TMSB4X protein {ECO:0000313|EMBL:AAH64954.1} Q0P5U7 [Target identity:100%; Query identity:67%]TMSB4X protein {ECO:0000313|EMBL:AAH61586.1} Q0P5P4 [Target identity:100%; Query identity:63%]TMSB4X protein {ECO:0000313|EMBL:AAH92437.1} Q0P5Q0 [Target identity:100%; Query identity:63%]TMSB4X protein {ECO:0000313|EMBL:AAH83509.1} Q0P5N8 [Target identity:100%; Query identity:62%]TMSB4X protein {ECO:0000313|EMBL:AAI04667.1}
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Show »
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Predicted intracellular proteins Plasma proteins Cytoskeleton related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
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44 |
5.1 |
No |
0 |
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