HBA1

GENE INFORMATION

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Gene name

HBA1 (HGNC Symbol)

Synonyms

HBA-T3

Description

Hemoglobin, alpha 1 (HGNC Symbol)

Entrez gene summary

The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

p13.3

Chromosome location (bp)

176680 - 177522

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000206172 (version 78.38)

Entrez gene

3039

UniProt

P69905 (UniProt - Evidence at protein level)

neXtProt

NX_P69905

Antibodypedia

HBA1 antibodies
 

PROTEIN VIEW

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HBA1-001
 
HBA1-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HBA1-001 ENSP00000322421
ENST00000320868
P69905
Show all »
Show » Show » 142 15.3 No 0
HBA1-006 ENSP00000380899
ENST00000397797
G3V1N2
Show all »
Show » Show » 110 11.9 No 0