ASIC3

GENE INFORMATION

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Gene name

ASIC3 (HGNC Symbol)

Synonyms

ACCN3, DRASIC, TNaC1

Description

Acid-sensing (proton-gated) ion channel 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

Chromosome

7

Cytoband

q36.1

Chromosome location (bp)

151048292 - 151052756

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000213199 (version 78.38)

Entrez gene

9311

UniProt

Q9UHC3 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UHC3

Antibodypedia

ASIC3 antibodies
 

PROTEIN VIEW

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ASIC3-001
 
ASIC3-003
 
ASIC3-005
 
ASIC3-007
 
ASIC3-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ASIC3-001 ENSP00000350600
ENST00000357922
Q9UHC3
Show all »
Show » Show » 543 60.3 No 2
ASIC3-003 ENSP00000344838
ENST00000349064
Q9UHC3
Show all »
Show » Show » 531 58.9 No 2
ASIC3-005 ENSP00000297512
ENST00000297512
Q9UHC3
Show all »
Show » Show » 549 60.5 No 2
ASIC3-007 ENSP00000418361
ENST00000490540
H7C4W0
Show all »
Show » Show » 149 16.6 No 1
ASIC3-009 ENSP00000420371
ENST00000485929
Show » Show » 144 15.9 No 1