TREX1

GENE INFORMATION

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Gene name

TREX1 (HGNC Symbol)

Synonyms

AGS1, DRN3

Description

Three prime repair exonuclease 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

Chromosome

3

Cytoband

p21.31

Chromosome location (bp)

48465046 - 48467645

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000213689 (version 78.38)

Entrez gene

11277

UniProt

Q9NSU2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NSU2

Antibodypedia

TREX1 antibodies
 

PROTEIN VIEW

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TREX1-002
 
TREX1-003
 
TREX1-004
 
TREX1-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TREX1-002 ENSP00000296443
ENST00000296443
Q9NSU2
Show all »
Show » Show » 314 33.2 No 1
TREX1-003 ENSP00000412404
ENST00000433541
C9J052
Show all »
Show » Show » 175 18.4 No 1
TREX1-004 ENSP00000415972
ENST00000444177
Q9NSU2
Show all »
Show » Show » 304 32.3 No 1
TREX1-005 ENSP00000411331
ENST00000456089
C9J052
Show all »
Show » Show » 175 18.4 No 1