ATP6V1G2

GENE INFORMATION

? »

Gene name

ATP6V1G2 (HGNC Symbol)

Synonyms

ATP6G, ATP6G2, Em:AC004181.3, NG38, Vma10

Description

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 (HGNC Symbol)

Entrez gene summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of three V1 domain G subunit proteins. This gene had previous gene symbols of ATP6G and ATP6G2. Alternatively spliced transcript variants encoding different isoforms have been described. Read-through transcription also exists between this gene and the downstream DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B (DDX39B) gene. [provided by RefSeq, Feb 2011]

Chromosome

6

Cytoband

p21.33

Chromosome location (bp)

31544462 - 31548427

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000213760 (version 78.38)

Entrez gene

534

UniProt

O95670 (UniProt - Evidence at protein level)

neXtProt

NX_O95670

Antibodypedia

ATP6V1G2 antibodies
 

PROTEIN VIEW

? »
 
 
 
ATP6V1G2-001
 
ATP6V1G2-002
 
ATP6V1G2-003
 
ATP6V1G2-007
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP6V1G2-001 ENSP00000302194
ENST00000303892
O95670
Show all »
Show » Show » 118 13.6 No 0
ATP6V1G2-002 ENSP00000365321
ENST00000376151
O95670
Show all »
Show » Show » 78 9 No 0
ATP6V1G2-003 ENSP00000419698
ENST00000483251
O95670
Show all »
Show » Show » 77 9 No 0
ATP6V1G2-007 ENSP00000390148
ENST00000415099
H0Y474
Show all »
Show » Show » 158 16.9 No 0