HBG1

GENE INFORMATION

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Gene name

HBG1 (HGNC Symbol)

Synonyms

HBG-T2

Description

Hemoglobin, gamma A (HGNC Symbol)

Entrez gene summary

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p15.4

Chromosome location (bp)

5248083 - 5249892

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000213934 (version 78.38)

Entrez gene

3047

UniProt

P69891 (UniProt - Evidence at protein level)

neXtProt

NX_P69891

Antibodypedia

HBG1 antibodies
 

PROTEIN VIEW

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HBG1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HBG1-001 ENSP00000327431
ENST00000330597
P69891
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