DHFR

GENE INFORMATION

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Gene name

DHFR

Synonyms

Description

Dihydrofolate reductase (HGNC Symbol)

Entrez gene summary

Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]

Chromosome

5

Cytoband

q14.1

Chromosome location (bp)

80626228 - 80654983

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000228716 (version 78.38)

Entrez gene

1719

UniProt

P00374 (UniProt - Evidence at protein level)

neXtProt

NX_P00374

Antibodypedia

DHFR antibodies
 

PROTEIN VIEW

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DHFR-001
 
DHFR-003
 
DHFR-005
 
DHFR-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DHFR-001 ENSP00000396308
ENST00000439211
P00374
Show all »
Show » Show » 187 21.5 No 0
DHFR-003 ENSP00000421334
ENST00000504396
P00374
Show all »
Show » Show » 135 15.7 No 0
DHFR-005 ENSP00000422732
ENST00000511032
B4DM58
Show all »
Show » Show » 129 14.5 No 0
DHFR-006 ENSP00000426474
ENST00000505337
P00374
Show all »
Show » Show » 187 21.5 No 0