DEFA3

GENE INFORMATION

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Gene name

DEFA3 (HGNC Symbol)

Synonyms

DEF3, HNP-3

Description

Defensin, alpha 3, neutrophil-specific (HGNC Symbol)

Entrez gene summary

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation. [provided by RefSeq, Oct 2014]

Chromosome

8

Cytoband

p23.1

Chromosome location (bp)

6996837 - 7018301

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000239839 (version 78.38)

Entrez gene

1668

UniProt

P59666 (UniProt - Evidence at protein level)

neXtProt

NX_P59666

Antibodypedia

DEFA3 antibodies
 

PROTEIN VIEW

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DEFA3-001
 
DEFA3-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DEFA3-001 ENSP00000328359
ENST00000327857
P59666
Show all »
Show » Show » 94 10.2 Yes 0
DEFA3-201 ENSP00000484218
ENST00000616150
Show » Show » 94 10.2 Yes 0