DEFA1B

GENE INFORMATION

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Gene name

DEFA1B

Synonyms

Description

Defensin, alpha 1B (HGNC Symbol)

Entrez gene summary

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

Chromosome

8

Cytoband

p23.1

Chromosome location (bp)

6996766 - 7018289

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000240247 (version 78.38)

Entrez gene

728358

UniProt

P59665 (UniProt - Evidence at protein level)

neXtProt

NX_P59665

Antibodypedia

DEFA1B antibodies
 

PROTEIN VIEW

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DEFA1B-001
 
DEFA1B-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DEFA1B-001 ENSP00000372136
ENST00000382689
P59665
Show all »
Show » Show » 94 10.2 Yes 0
DEFA1B-201 ENSP00000443526
ENST00000535841
P59665
Show all »
Show » Show » 94 10.2 Yes 0