SERPINB10

GENE INFORMATION

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Gene name

SERPINB10 (HGNC Symbol)

Synonyms

bomapin, PI10

Description

Serpin peptidase inhibitor, clade B (ovalbumin), member 10 (HGNC Symbol)

Entrez gene summary

The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by a well-conserved tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-10 (PI10; SERPINB10) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]).[supplied by OMIM, Jan 2010]

Chromosome

18

Cytoband

Chromosome location (bp)

63897174 - 63936111

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000242550 (version 78.38)

Entrez gene

5273

UniProt

P48595 (UniProt - Evidence at protein level)

neXtProt

NX_P48595

Antibodypedia

SERPINB10 antibodies
 

PROTEIN VIEW

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SERPINB10-001
 
SERPINB10-002
 
SERPINB10-003
 
SERPINB10-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SERPINB10-001 ENSP00000238508
ENST00000238508
P48595
Show all »
Show » Show » 397 45.4 No 0
SERPINB10-002 ENSP00000381082
ENST00000397996
Show » 280 31.4 No 0
SERPINB10-003 ENSP00000392381
ENST00000418725
Show » 253 28.5 No 0
SERPINB10-201 ENSP00000479385
ENST00000619595
P48595
Show all »
Show » Show » 397 45.4 No 0