CNTF

GENE INFORMATION

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Gene name

CNTF (HGNC Symbol)

Synonyms

HCNTF

Description

Ciliary neurotrophic factor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010]

Chromosome

11

Cytoband

q12.1

Chromosome location (bp)

58622673 - 58625733

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000242689 (version 78.38)

Entrez gene

1270

UniProt

P26441 (UniProt - Evidence at protein level)

neXtProt

NX_P26441

Antibodypedia

CNTF antibodies
 

PROTEIN VIEW

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CNTF-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CNTF-001 ENSP00000355370
ENST00000361987
P26441
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