PSG4

GENE INFORMATION

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Gene name

PSG4

Synonyms

Description

Pregnancy specific beta-1-glycoprotein 4 (HGNC Symbol)

Entrez gene summary

The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]

Chromosome

19

Cytoband

q13.31

Chromosome location (bp)

43192702 - 43207299

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000243137 (version 78.38)

Entrez gene

5672

UniProt

Q00888 (UniProt - Evidence at transcript level)

neXtProt

NX_Q00888

Antibodypedia

PSG4 antibodies
 

PROTEIN VIEW

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PSG4-001
 
PSG4-003
 
PSG4-004
 
PSG4-006
 
PSG4-008
 
PSG4-009
 
PSG4-010
 
PSG4-011
 
PSG4-015
 
PSG4-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSG4-001 ENSP00000384770
ENST00000405312
Q00888
Show all »
Show » Show » 419 47.1 Yes 0
PSG4-003 ENSP00000244295
ENST00000244295
Q00888
Show all »
Show » Show » 326 36.3 Yes 0
PSG4-004 ENSP00000388134
ENST00000451895
C9JWP2
Show all »
Show » Show » 252 28.1 No 0
PSG4-006 ENSP00000470073
ENST00000600572
M0QYU2
Show all »
Show » 78 8.8 No 0
PSG4-008 ENSP00000472818
ENST00000599371
Show » Show » 96 10.6 No 0
PSG4-009 ENSP00000471124
ENST00000596907
M0R0B3
Show all »
Show » Show » 292 32.8 No 0
PSG4-010 ENSP00000469547
ENST00000599746
Show » Show » 244 27.8 No 0
PSG4-011 ENSP00000472885
ENST00000599391
M0R2Y7
Show all »
Show » Show » 180 20 No 0
PSG4-015 ENSP00000472423
ENST00000597374
Show » Show » 258 29.3 No 0
PSG4-201 ENSP00000387864
ENST00000433626
Q00888
Show all »
Show » Show » 326 36.8 Yes 0